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. 2023 Oct:190:104081.
doi: 10.1016/j.critrevonc.2023.104081. Epub 2023 Aug 2.

Risk factors for developing both primary breast and primary ovarian cancer: A systematic review

Jennifer S Ferris  1 , Devon A Morgan  2 , Ashley S Tseng  2 , Mary Beth Terry  3 , Ruth Ottman  4 , Chin Hur  5 , Jason D Wright  6 , Jeanine M Genkinger  3
Affiliations

Risk factors for developing both primary breast and primary ovarian cancer: A systematic review

Jennifer S Ferris et al. Crit Rev Oncol Hematol. 2023 Oct.

Abstract

Objective: Women with breast cancer have an increased risk of primary ovarian cancer (BR→OV), and women with ovarian cancer have an increased risk of primary breast cancer (OV→BR). This systematic review summarizes risk factors for developing BR→OV and OV→BR.

Methods: We searched PubMed and Embase until June 2022.

Results: We identified 23 articles meeting our inclusion criteria. Studies observed a lower risk of BR→OV for Black versus White women, alcohol consumption, radiotherapy and hormone therapy, BRCA2 versus BRCA1, and ER/PR positive versus negative breast tumors, and a higher risk with family history of breast/ovarian cancer, triple negative versus luminal breast cancer, and higher grade breast tumors. There was an increased risk of OV→BR with family history of cancer.

Conclusions: Tumor characteristics, and genetic and familial factors are associated with risk of BR→OV and OV→BR. These results could aid clinicians in decision-making for breast and ovarian cancer patients, including risk-reducing strategies.

Keywords: Breast cancer; Ovarian cancer; Risk Factors; Second cancers; Systematic Review.

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Conflict of interest statement

Declaration of Competing Interest Dr. Wright has received royalties from UpToDate and research support from Merck. All other authors have no conflicts of interest.

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