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Comment
. 2023 Sep 11;62(37):e202306059.
doi: 10.1002/anie.202306059. Epub 2023 Aug 4.

Reply to Correspondence on "Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1''

Lian Wu  1 , Zhanfeng Wang  2 , Yixin Cen  3 , Binju Wang  2 , Jiahai Zhou  4
Affiliations
Comment

Reply to Correspondence on "Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1''

Lian Wu et al. Angew Chem Int Ed Engl. .

Abstract

The high-resolution X-ray crystal structure of the ternary complex FtmOx1 ⋅ 2OG ⋅ fumitremorgin B and the catalytic mechanism were recently reported by us (DOI 10.1002/anie.202112063). In their Correspondence, Zhang, Costello, Liu et al. criticize our work in several aspects. Herein, we address these questions one by one. These structural clarifications and new computational results further support the CarC-like mechanistic model.

Keywords: Biosynthesis; Endoperoxides; Ftmox1; Iron; Non-Heme Enzymes.

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References

    1. None
    1. L. Wu, Z. F. Wang, Y. X. Cen, B. J. Wang, J. H. Zhou, Angew. Chem. Int. Ed. 2022, 61, e202112063;
    1. L. Zhang, X. Liu, X. Wang, G. Zhu, H. Song, R. Cheng, N. Naowarojna, C. E. Costello, P. Liu, Angew. Chem. Int. Ed. 2023, e202118643.
    1. W. Yan, H. Song, F. Song, Y. Guo, C. H. Wu, A. S. Her, Y. Pu, S. Wang, N. Naowarojna, A. Weitz, M. P. Hendrich, C. E. Costello, L. Zhang, P. Liu, Y. J. Zhang, Nature 2015, 527, 539-543; editorially retracted.
    1. W. Yan, H. Song, F. Song, Y. Guo, C.-H. Wu, A. S. Her, Y. Pu, S. Wang, N. Naowarojna, A. Weitz, M. P. Hendrich, C. E. Costello, L. Zhang, P. Liu, Y. J. Zhang, Nature 2021, 593, 612-612.

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