Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jan;63(1):95-100.

Antibodies to wheat germ agglutinin in coeliac disease

L M Sollid, J Kolberg, H Scott, J Ek, O Fausa, P Brandtzaeg

Antibodies to wheat germ agglutinin in coeliac disease

L M Sollid et al. Clin Exp Immunol. 1986 Jan.

Abstract

Serum IgG and IgA antibodies to wheat germ agglutinin (WGA) were measured by an enzyme-linked immunosorbent assay (ELISA) with N-acetyl-D-glucosamine in all incubation steps to inhibit sugar-specific binding. Patients with coeliac disease (CD) had significantly higher antibody levels to WGA than patients with other intestinal disorders or healthy controls. Similar results were obtained for antibodies to the gluten fraction glyc-gli. The WGA antibodies did apparently not cross-react with gluten antigens, but commercial gluten powder contained traces of WGA or a similar lectin. Our findings support the proposal that WGA may be involved in the pathogenesis of CD.

PubMed Disclaimer

References

    1. Gut. 1970 Aug;11(8):635-40 - PubMed
    1. Biochem Biophys Res Commun. 1985 Jul 31;130(2):867-72 - PubMed
    1. Science. 1972 Sep 15;177(4053):949-59 - PubMed
    1. Biochem Biophys Res Commun. 1974 Jul 10;59(1):414-9 - PubMed
    1. Lancet. 1976 Mar 13;1(7959):567-9 - PubMed

Publication types

LinkOut - more resources