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Observational Study
. 2023 Nov;47(11):2825-2833.
doi: 10.1007/s00268-023-07122-1. Epub 2023 Aug 4.

Sarcopenia and Sarcopenic Obesity on Body Composition Analysis is a Significant Predictor of Mortality in Severe Acute Pancreatitis: A Longitudinal Observational Study

Robert Farquhar  1 , Scott Matthews  2 , Nesta Baxter  3 , George Rayers  3 , Chathura B B Ratnayake  4 , Francis P Robertson  5 , Sandip Nandhra  5 , Wei Boon Lim  3 , Miles Witham  6 , Sanjay Pandanaboyana  5   6
Affiliations
Observational Study

Sarcopenia and Sarcopenic Obesity on Body Composition Analysis is a Significant Predictor of Mortality in Severe Acute Pancreatitis: A Longitudinal Observational Study

Robert Farquhar et al. World J Surg. 2023 Nov.

Abstract

Background: The prevalence and impact of sarcopenia and sarcopenic obesity noted on body composition analysis in severe acute pancreatitis (SAP) is unknown. This study investigates the prevalence of sarcopenia at different timepoints and its effect on post-pancreatitis complications and mortality.

Methods: A prospective database of SAP admissions with organ failure at a single institution from 2015 to 2019 were analysed. Sarcopenia was determined by IMAGE J software on CT. Database was further queried for post-pancreatitis complications and mortality.

Results: 141 patients with a median age of 59 (range 18-88) and M:F ratio 1.52:1 of were analysed. Sarcopenia was present in 111/141 (79%) patients at admission, 78/79 (99%) at 3 months and 26/36 (72%) at 12 months. 67/111 patients with sarcopenia on admission had sarcopenic obesity. The mortality at 30 days, 3 months and 12 months was 16/141 (11%), 30/141 (21%) and 42/141 (30%) respectively. Mortality was significantly higher in sarcopenic patients at admission (35.14%) compared to the non-sarcopenic group (10%), P = 0.008). Mortality in the sarcopenic obesity group was significantly higher (45%) compared to the sarcopenic non-obese group (20%), P = 0.009) at admission. Multivariate logistic regression identified sarcopenic obesity (OR: 2.880), age (OR: 1.048) and number of organ failures (OR: 3.225) as significant predictors of mortality.

Conclusions: Sarcopenia and Sarcopenic obesity are highly prevalent in SAP patients on admission and during follow up. Furthermore, sarcopenic obesity was shown to be a significant predictor of mortality at admission, suggesting that body composition analysis could be a potential predictive marker of mortality in SAP patients.

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Conflict of interest statement

The authors disclose no conflicts of interest.

Figures

Fig. 1
Fig. 1
Flow chart summarising mortality and proportion of patients with Sarcopenia at admission, 6 weeks, 3 months, 6 months, and 12 months post admission
Fig. 2
Fig. 2
KM Curve of survival analysis of Non-sarcopenic (NSARC), sarcopenic (SARC) and sarcopenic obese patients
See this image and copyright information in PMC

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