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Clinical Trial
. 2023 Aug 4;23(1):540.
doi: 10.1186/s12903-023-03263-w.

Potential use of optical coherence tomography in oral potentially malignant disorders: in-vivo case series study

Alessio Gambino  1 , Eugenio Martina  2 , Vera Panzarella  3 , Tiziana Ruggiero  2 , Giorgia El Haddad  2 , Roberto Broccoletti  2 , Paolo G Arduino  2
Affiliations
Clinical Trial

Potential use of optical coherence tomography in oral potentially malignant disorders: in-vivo case series study

Alessio Gambino et al. BMC Oral Health. .

Erratum in

Abstract

Background: Evidence confirms that the use of Optical Coherence Tomography (OCT) in oral medicine can be a reliable aid for the diagnosis and management of Oral Potentially Malignant Disorders (OPMDs). Several authors described the ability of this system to detect the structural changes of the epithelia involved by the OPMDs. The purpose of this case series is to provide a suggestion for interpretation of OCT images from different OPMDs, compared to OCT images of healthy tissues.

Methods: A sample of 11 OPMDs patients was recruited and analyzed with OCT. The images obtained were then compared with an OCT repertoire image. In this work the reflectance degree was considered, together with the analysis of the increased/decreased thicknesses of the various layers. Keratin Layer (KL), Epithelial Layer (EP), Lamina Propria (LP), Basal Membrane (BM) assessment, for each lesion, was performed.

Results: OCT measurements of KL, EP and LP layers, together with BM assessing, should aid the physicians to recognize and describe different oral lesions, relating them to the corresponding oral pathology.

Conclusion: More studies like this, on larger samples, are needed to validate the results and provide, in the future, a kind of manual that could guide clinicians to correctly interpret the OCT images in relation to the causing pathologies.

Trial registration: The present trial has been registered with ISRCTN (#17,893,224).

Keywords: Optical coherence tomography; Oral cancer; Oral potential malignant disorders; Oral soft tissue.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Prototype of manual probe for intraoral use
Fig. 2
Fig. 2
a Healthy OCT scan of dorsum of the tongue. b White lesion OCT scan of dorsum of the tongue. c Clinical image of withe lesion of dorsum of the tongue
Fig. 3
Fig. 3
a Healthy OCT scan of ventral tongue surface. b Withe lesion OCT scan of ventral tongue surface. c Clinical image of withe lesion of ventral tongue surface
Fig. 4
Fig. 4
a Healthy OCT scan of ventral tongue surface. b Ulcer OCT scan of ventral tongue surface. c Clinical image of ulcer of ventral tongue surface
Fig. 5
Fig. 5
a Healthy OCT scan of tongue border surface. b White lesion OCT scan of border surface of tongue. c Clinical image of with lesion compatible with OLP of ventral surface of tongue
Fig. 6
Fig. 6
a Healthy OCT scan of tongue border surface. b White lesion OCT scan of of tongue border surface. c Clinical image of with lesion compatible with leukoplakia of tongue border surface
Fig. 7
Fig. 7
a Healthy OCT scan of tongue border surface. b Ulcer OCT scan of border surface of tongue. c Clinical image of ulcer of tongue border surface
Fig. 8
Fig. 8
a Healthy OCT scan of buccal mucosa. b White lesion OCT scan of buccal mucosa. c Clinical image of withe lesion of buccal mucosa
Fig. 9
Fig. 9
a Healthy OCT scan of buccal mucosa. b White lesion OCT scan of buccal mucosa. c Clinical image of withe lesion of buccal mucosa
Fig. 10
Fig. 10
a Healthy OCT scan of buccal mucosa. b Ulcer OCT scan of buccal mucosa. c Clinical image of ulcer of buccal mucosa
Fig. 11
Fig. 11
a Healthy OCT scan of adherent gingiva. b White lesion OCT scan of adherent gingiva. c Clinical image of withe lesion of adherent gingiva
Fig. 12
Fig. 12
a Healthy OCT scan of adherent gingiva. b White and red lesion OCT scan of adherent gingiva. c Clinical image of withe and red lesion of adherent gingiva
See this image and copyright information in PMC

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