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Review
. 2023 Aug 4;102(31):e34613.
doi: 10.1097/MD.0000000000034613.

A bibliometric analysis of exosomes in sepsis from 2004 to 2022

Yuanyuan Li  1 , Weina Wang  1 , Bo Zhang  1 , Lili Li  2 , Dengfeng Zhou  1
Affiliations
Review

A bibliometric analysis of exosomes in sepsis from 2004 to 2022

Yuanyuan Li et al. Medicine (Baltimore). .

Abstract

The study aims to summarize topical and frontier issues in sepsis and exosomes and provide advice and resources for researchers working in related disciplines. Publications on exosomes in sepsis from 2004 to 2022 were extracted from the Web of Science Core Collection database. VOSviewer 1.6.18 and CiteSpace 6.1.3 were used to conduct the bibliometric analysis. The number of publications on exosomes in sepsis showed a rapidly rising trend globally. China and the United States were the most published countries. Shanghai Jiao Tong University is the most prolific institution. Frontiers in Immunology was one of the journals with the highest number of papers. Journal of Immunology was the most co-cited journal. Ping Wang was the most productive author. Clotilde Thery was the author who has been cited the most times among co-cited authors. Singer m, 2016, Jama-j am med assoc was the most co-cited reference. "Mesenchymal stem cells derived exosomes," "microRNAs," "apoptosis," and "immunomodulatory therapy" are the current research hot spots and frontiers. This study provides a comprehensive overview of the current status and trends in sepsis and exosomal research. Researchers working in this area will benefit from the hot spots and trends of exosomes in sepsis discovered through this study.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Publications screening flowchart.
Figure 2.
Figure 2.
The annual number of publications.
Figure 3.
Figure 3.
The visualization of countries on the research of exosomes in sepsis.
Figure 4.
Figure 4.
The visualization of institutions on the research of exosomes in sepsis.
Figure 5.
Figure 5.
The visualization of journals coupling on the research of exosomes in sepsis.
Figure 6.
Figure 6.
The visualization of co-cited journals on the research of exosomes in sepsis.
Figure 7.
Figure 7.
The visualization of authors coupling (A) and co-cited authors (B) on the research of exosomes in sepsis.
Figure 8.
Figure 8.
The visualization of co-cited references on the research of exosomes in sepsis (A) and the top 10 references with strong citation bursts (B).
Figure 9.
Figure 9.
Keyword cluster analysis (A) and keywords with the strongest citation bursts on the research of exosomes in sepsis (B).
See this image and copyright information in PMC

References

    1. Rudd KE, Johnson SC, Agesa KM, et al. . Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study. Lancet. 2020;395:200–11. - PMC - PubMed
    1. Xie J, Wang H, Kang Y, et al. . Chinese Epidemiological Study of Sepsis (CHESS) Study Investigators. The epidemiology of sepsis in Chinese ICUs: a national cross-sectional survey. Crit Care Med. 2020;48:e209–18. - PubMed
    1. Heming N, Azabou E, Cazaumayou X, et al. . Sepsis in the critically ill patient: current and emerging management strategies. Expert Rev Anti Infect Ther. 2021;19:635–47 - PubMed
    1. Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200:373–83. - PMC - PubMed
    1. Pan BT, Johnstone RM. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell. 1983;33:967–78. - PubMed