doi: 10.1002/cplu.202300314.
Epub 2023 Aug 21.
Gold-Catalyzed Asymmetric Transformation of Hydroxylated Propargylic Esters
Affiliations
- PMID: 37544902
- PMCID: PMC11419700
- DOI: 10.1002/cplu.202300314
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Gold-Catalyzed Asymmetric Transformation of Hydroxylated Propargylic Esters
Chempluschem.
2023 Oct.
Abstract
By combining tandem asymmetric gold catalysis and subsequent stereoconvergent hydrolysis of enol ester in a one-pot process, hydroxylated propargylic esters are converted into chiral β-oxygenated ketones with mostly good enantiomeric ratios and in largely good to excellent yields. The product chiral center is formed via stereoselective cyclization of a hydroxylated allenyl ester intermediate, which is enabled by asymmetric gold-ligand cooperation.
Keywords: catalysis; chiral; gold; ligand; metal-ligand cooperation.
© 2023 Wiley-VCH GmbH.
Conflict of interest statement
Conflict of Interests
The authors declare no conflict of interest.
Figures
Gold-catalyzed asymmetric allenol cyclization achieved via metal-ligand cooperation: a previous study and this work.
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