The in-vitro activity of SQ 82,291, a new monobactam, in comparison with aztreonam

Abstract

The in-vitro activity of a new monobactam antibiotic, SQ 82,291, was compared with that of aztreonam against 529 strains of aerobic and facultatively anaerobic bacteria. SQ 82,291, which is absorbed orally when administered as an ester, has shown good activity against different bacteria of the family Enterobacteriaceae and Haemophilus influenzae. The susceptibility of SQ 82,291 is lower than that to aztreonam in the species that were sensitive and SQ 82,291 showed no activity at all against staphylococci and strict anaerobes (like aztreonam); unlike aztreonam SQ 82,291 was not effective against Pseudomonas aeruginosa.