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Meta-Analysis
. 2023 Mar;23(1):614-621.
doi: 10.4314/ahs.v23i1.65.

Ginger supplementation for the treatment of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials

Qun Zhou  1 , Ying Peng  2 , Fangyuan Chen  2 , Jianbo Dai  3
Affiliations
Meta-Analysis

Ginger supplementation for the treatment of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials

Qun Zhou et al. Afr Health Sci. 2023 Mar.

Abstract

Introduction: The efficacy of ginger supplementation remains controversial for non-alcoholic fatty liver disease. We conduct this meta-analysis to explore the influence of ginger supplementation versus placebo on the treatment of non-alcoholic fatty liver disease.

Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 2021 and included randomized controlled trials (RCTs) assessing the efficacy of ginger supplementation versus placebo for non-alcoholic fatty liver disease. This meta-analysis was performed using the random-effect model.

Results: Four RCTs involving 177 patients were included in the meta-analysis. Overall, compared with non-alcoholic fatty liver disease, ginger supplementation was associated with significantly reduced alanine aminotransferase (ALT, standard mean difference (SMD)=-0.43; 95% confidence interval [CI]=-0.85 to -0.02; P=0.04), homeostatic Model Assessment of Insulin Resistance (HOMA-IR, SMD=-1.14; 95% CI=-2.05 to -0.22; P=0.02), but revealed no obvious impact on aspartate-aminotransferase (AST, SMD=-0.66; 95% CI=-0.81 to 2.12; P=0.38), total cholesterol (SMD=-0.33; 95% CI=-0.67 to 0.02; P=0.06), low density lipoprotein (LDL, SMD=-0.30; 95% CI=-0.64 to 0.04; P=0.08) or body mass index (BMI, SMD=0; 95% CI=-0.41 to 0.40; P=0.99).

Conclusions: Ginger supplementation benefits to treat non-alcoholic fatty liver disease.

Keywords: ginger; meta-analysis; non-alcoholic fatty liver disease; randomized controlled trials.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of study searching and selection process.
Figure 2
Figure 2
Forest plot for the meta-analysis of ALT.
Figure 3
Figure 3
Forest plot for the meta-analysis of AST.
Figure 4
Figure 4
Forest plot for the meta-analysis of HOMA-IR
Figure 5
Figure 5
Forest plot for the meta-analysis of total cholesterol.
Figure 6
Figure 6
Forest plot for the meta-analysis of LDL.
Figure 7
Figure 7
Forest plot for the meta-analysis of BMI.
See this image and copyright information in PMC

References

    1. Younossi ZM. Non-alcoholic fatty liver disease - A global public health perspective. Journal of hepatology. 2019;70(3):531–544. - PubMed
    1. Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology (Baltimore, Md.) 2009;49(1):306–317. - PMC - PubMed
    1. Neuschwander-Tetri BA. Non-alcoholic fatty liver disease. BMC medicine. 2017;15(1):45. - PMC - PubMed
    1. Katsiki N, Mikhailidis DP, Mantzoros CS. Non-alcoholic fatty liver disease and dyslipidemia: An update, Metabolism. clinical and experimental. 2016;65(8):1109–1123. - PubMed
    1. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, Natale S, Vanni E, Villanova N, Melchionda N, Rizzetto M. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology (Baltimore, Md.) 2003;37(4):917–923. - PubMed

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