Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar;23(1):704-710.
doi: 10.4314/ahs.v23i1.75.

Prevalence of acute kidney injury and its characteristics among neonates with suspected sepsis in a tertiary hospital in Kenya

Catherine Munyendo  1   2 , Bashir Admani  1 , Patrick Mburugu  3 , Justus Simba  3 , Bernadine Lusweti  2 , Naomi Gachara  4 , Ahmed Laving  1
Affiliations

Prevalence of acute kidney injury and its characteristics among neonates with suspected sepsis in a tertiary hospital in Kenya

Catherine Munyendo et al. Afr Health Sci. 2023 Mar.

Abstract

Introduction: Unique aspects of neonatal renal physiology enhance the occurrence of Acute Kidney Injury (AKI) as a complication of neonatal sepsis. The study sought to determine prevalence of AKI and its characteristics in neonates with suspected sepsis.

Methods: A cross-sectional study was conducted at Kenyatta National Hospital among neonates aged 0-28 days. AKI was defined as serum creatinine of more than 100µmmol/l.

Results: Among 332 neonates included 120 had AKI giving a prevalence of 36.1% (95% CI 31 to 41.6). Based on RIFLE criteria the commonest AKI presentation was Failure 72 (62.6%, 95% CI 53.6 to 71.6), followed by Injury 26 (22.6%, 95% CI 14.8 to 30.4) and then Risk 17 (14.8%, 95% CI 8.2 to 21.3). AKI was more common in neonates with suspected late onset sepsis (p=0.004). Maternal fever in the preceding week to delivery and presence of either puerperal sepsis or post-partum hemorrhage were significantly associated with severe AKI (p=0.004 and p=0.038).

Conclusion: Prevalence of AKI was high; those with suspected late onset sepsis were more likely to develop AKI compared to early onset sepsis. Presence of maternal fever preceding delivery and presence of either puerperal sepsis or postpartum hemorrhage were associated with severe forms of AKI.

Keywords: Acute Kidney Injury; Neonatal Sepsis; Neonates.

PubMed Disclaimer

Conflict of interest statement

Authors of this article disclose no conflict of interest in this study and its publication.

References

    1. Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. The Lancet. 2015;385(9966):430–440. - PubMed
    1. 2014 Kenya Demographic and Health Survey (2014 KDHS) [Internet] [cited 2016 Mar 17]. Available from: http://www.knbs.or.ke/index.php?option=com_content&view=article&id=308:2....
    1. Simiyu DE. Morbidity and mortality of neonates admitted in general paediatric wards at Kenyatta National Hospital. East Afr Med J. 2003 Dec;80(12):611–616. - PubMed
    1. Selewski DT, Charlton JR, Jetton JG, Guillet R, Mhanna MJ, Askenazi DJ, et al. Neonatal Acute Kidney Injury. Pediatrics. 2015 Jul 13; peds.2014-3819. - PubMed
    1. Sulemanji M, Vakili K. Neonatal renal physiology. Semin Pediatr Surg. 2013 Nov;22(4):195–198. - PubMed

LinkOut - more resources