Neonatal lupus erythematosus manifested as a complete heart block: A case report
- PMID: 37546163
- PMCID: PMC10397475
- DOI: 10.1002/ccr3.7758
Neonatal lupus erythematosus manifested as a complete heart block: A case report
Abstract
Key clinical message: Fetal bradycardia and congenital complete heart block could be the presentation of neonatal lupus. A high index of suspicion of this condition helps to identify an asymptomatic mother.
Abstract: Neonatal lupus erythematosus (NLE) is a rare acquired autoimmune disease of newborns due to placental transfer of Ro/SSA or La/SSB autoantibodies. Though cardiac, cutaneous, hematological, and hepatobiliary abnormalities are detected, cardiac defects cause significant morbidity and mortality. We report a case of complete congenital heart block due to NLE.
Keywords: autoantibodies; bradycardia; heart block.
© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
Conflict of interest statement
The authors declare that there is no conflict of interest regarding the publication of this paper.
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References
-
- Garcia S, Campos‐de‐Carvalho AC. Neonatal lupus syndrome: the heart as a target of the immune system. An Acad Bras Cienc. 2000;72(1):83‐89. - PubMed
-
- Diaz‐Frias J, Badri T. Neonatal Lupus Erythematosus. StatPearls. Treasure Island; 2022. - PubMed
-
- Wei S, Yuan TM, Chen LH, Yu HM. Neonatal lupus erythematosus: three case reports and review of the Chinese literature. Clin Pediatr (Phila). 2010;49(7):627‐634. - PubMed
-
- Buyon JP, Clancy RM. Neonatal lupus syndromes. Curr Opin Rheumatol. 2003;15(5):535‐541. - PubMed
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