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. 1986 Apr;320(6064):695-9.
doi: 10.1038/320695a0.

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

C Betsholtz, A Johnsson, C H Heldin, B Westermark, P Lind, M S Urdea, R Eddy, T B Shows, K Philpott, A L Mellor, et al.

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

C Betsholtz et al. Nature. 1986 Apr.

Abstract

The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.

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