Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 15;15(7):1174-1181.
doi: 10.4251/wjgo.v15.i7.1174.

Clinical value of serum pepsinogen in the diagnosis and treatment of gastric diseases

Yuan Qin  1 , Jia-Xin Geng  1 , Biao Huang  2
Affiliations
Review

Clinical value of serum pepsinogen in the diagnosis and treatment of gastric diseases

Yuan Qin et al. World J Gastrointest Oncol. .

Abstract

Pepsinogen, secreted from the gastric mucosa, is the precursor of pepsin. It is categorized as pepsinogen 1 and pepsinogen 2 based on its immunogenicity. The pepsinogen content that can enter the blood circulation through the capillaries of the gastric mucosa is approximately 1% and remains stable all the time. The pepsinogen content in serum will change with the pathological changes of gastric mucosa. Therefore, the level of pepsinogen in serum can play a role in serologic biopsy to reflect the function and morphology of different regions of gastric mucosa and serve as an indicator of gastric disease. This study conducts relevant research on serum pepsinogen 1, pepsinogen 2, and the ratio of pepsinogen 1 to pepsinogen 2, and reviews their important value in clinical diagnosis of Helicobacter pylori infection, gastric ulcer, and even gastric carcinoma, providing ideas for other researchers.

Keywords: Gastric diseases; Pepsinogen 1; Pepsinogen 2; Serological biopsy; Serological marker.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Figures

Figure 1
Figure 1
Expression of pepsinogen 1 and pepsinogen 2 in gastric mucosa.
Figure 2
Figure 2
Development of gastric mucosal lesion.
Figure 3
Figure 3
Relationship between serum pepsinogen level and gastric diseases. H. pylori: Helicobacter pylori.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kageyama T. Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. Cell Mol Life Sci. 2002;59:288–306. - PMC - PubMed
    1. Rotter JI, Sones JQ, Samloff IM, Richardson CT, Gursky JM, Walsh JH, Rimoin DL. Duodenal-ulcer disease associated with elevated serum pepsinogen I: an inherited autosomal dominant disorder. N Engl J Med. 1979;300:63–66. - PubMed
    1. Di Mario F, Crafa P, Barchi A, Franzoni L, Franceschi M, Russo M, Bricca L, Brozzi L, Rodriguez Castro K, Rugge M. Pepsinogen II in gastritis and Helicobacter pylori infection. Helicobacter. 2022;27:e12872. - PubMed
    1. Hamashima C. Forthcoming Step in Gastric Cancer Prevention: How Can Risk Stratification Be Combined with Endoscopic Screening for Gastric Cancer? Gut Liver. 2022;16:811–824. - PMC - PubMed
    1. Wang Y, Zhu Z, Liu Z, Zhao Z, Xue X, Li X, Li P, Rong G, Ma Y. Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer. J Int Med Res. 2020;48:300060520914826. - PMC - PubMed