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Editorial
. 2023 Jul 24;8(7):840-842.
doi: 10.1016/j.jacbts.2023.02.012. eCollection 2023 Jul.

BAG3 in the Heart

Maria Caterina Turco  1
Affiliations
Editorial

BAG3 in the Heart

Maria Caterina Turco. JACC Basic Transl Sci. .
No abstract available

Keywords: BAG3; apoptosis; caspase; metabolism; tumor necrosis factor.

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Conflict of interest statement

Prof. M. Caterina Turco is the C.E.O. of the academic spin-off FIBROSYS, developing diagnostic and therapeutic tools based on BAG3 protein and its receptor. The author has reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
See this image and copyright information in PMC

Comment on

  • doi: 10.1016/j.jacbts.2022.12.013

References

    1. Wang J., Tomar D., Martin T.G., et al. Bag3 regulates mitochondrial function and the inflammasome through canonical and non-canonical pathways in the heart. J Am Coll Cardiol Basic Trans Science. 2023;8(7):820–839. - PMC - PubMed
    1. Homma S., Iwasaki M., Shelton G.D., Engvall E., Reed J.C., Takayama S. BAG3 deficiency results in fulminant myopathy and early lethality. Am J Pathol. 2006;6:761–773. - PMC - PubMed
    1. Myers V.D., McClung J.M., Wang J., et al. The multifunctional protein BAG3: a novel therapeutic target in cardiovascular disease. J Am Coll Cardiol Basic Trans Science. 2018;3:122–131. - PMC - PubMed
    1. Takayama S., Xie Z., Reed J.C. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem. 1999;274:781–786. - PubMed
    1. De Marco M., Falco A., Basile A., et al. Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure. Cell Death Dis. 2013;4:e495. - PMC - PubMed

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