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Case Reports
. 2023 May 29;8(8):1687-1691.
doi: 10.1016/j.ekir.2023.05.017. eCollection 2023 Aug.

Avacopan in Patients With Rapidly Progressive Glomerulonephritis Requiring Dialysis

Frank B Cortazar  1   2 , Jorge Cerda  1   2 , Rahim Dhanani  1   2 , Joseph Roglieri  1   2 , Dominick Santoriello  3
Affiliations
Case Reports

Avacopan in Patients With Rapidly Progressive Glomerulonephritis Requiring Dialysis

Frank B Cortazar et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
(a) A representative glomerulus from case #1 exhibits segmental GBM glomerular basement membrane rupture (arrow) associated with fibrin extravasation into the urinary space and segmental cellular crescent formation. Marinating neutrophils, some of which are undergoing karyorrhexsis, are admixed with fibrin in several capillary loops (×200, Jones methenamine silver; JMS). (b) A representative glomerulus from case #2 displays a circumferential cellular crescent compressing the underlying glomerular tuft. There is also focal disruption of Bowman’s capsule (×200, JMS). (c) A segmental cellular crescent (arrow) from case #3’s kidney biopsy. The uninvolved portions of the glomerular tuft are normocellular with patent capillary lumina, typical of ANCA-mediated glomerulonephritis (×200, JMS). (d) Immunofluorescence staining for case #3 revealed intense (3+) linear staining of glomerular basement membranes for IgG, typical of anti- glomerular basement membrane- GBM disease. Foci of glomerular basement membrane GBM rupture were apparent (arrow). This patient was also found to have proteinase-3 PR3-ANCA seropositivity (×200, immunofluorescence microscopy).
See this image and copyright information in PMC

References

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