European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy

Joana Ferrer-Fàbrega^{1

2

3

4}, Benoît Mesnard^{5

6}, Franka Messner⁷, Jason B Doppenberg⁸, Cinthia Drachenberg⁹, Marten A Engelse⁸, Paul R V Johnson¹⁰, Henri G D Leuvenink¹¹, Gabriel C Oniscu¹², Vassilios Papalois¹³, Rutger J Ploeg¹⁴, Trevor W Reichman¹⁵, William E Scott 3rd¹⁶, Fabio Vistoli¹⁷, Thierry Berney¹⁸, Daniel Jacobs-Tulleneers-Thevissen^{19

20}, Nicos Kessaris²¹, Annemarie Weissenbacher⁷, Ann Etohan Ogbemudia¹⁴, Steve White²², Julien Branchereau^{5

6}

Affiliations

¹ Hepatobiliopancreatic Surgery and Liver and Pancreatic Transplantation Unit, Department of Surgery, Institute Clínic of Digestive and Metabolic Diseases (ICMDiM), Hospital Clínic, University of Barcelona, Barcelona, Spain.
² Hepatic Oncology Unit, Barcelona Clínic Liver Cancer Group (BCLC), Hospital Clínic, Barcelona, Spain.
³ August Pi i Sunyer Biomedical, Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.
⁴ Network for Biomedical Research in Hepatic and Digestive Diseases (CIBEREHD), Barcelona, Spain.
⁵ Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.
⁶ Centre for Research in Transplantation and Translational Immunology, INSERM UMR 1064, ITUN5, Nantes, France.
⁷ Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
⁸ Transplantation Center, Leiden University Medical Center, Leiden, Netherlands.
⁹ Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, United States.
¹⁰ Research Group for Islet Transplantation, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
¹¹ Department of Surgery, University Medical Center Groningen, Groningen, Netherlands.
¹² Transplant Division, Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Sweden.
¹³ Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
¹⁴ Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
¹⁵ Ajmera Transplant Centre, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
¹⁶ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
¹⁷ Division of General Surgery and Transplantation, University of Pisa, Pisa, Italy.
¹⁸ Division of Transplantation, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland.
¹⁹ Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.
²⁰ Department of Surgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
²¹ Department of Nephrology and Transplantation, Guy's Hospital, London, United Kingdom.
²² Department of HPB and Transplant Surgery, NIHR BTRU in Organ Donation and Transplantation, The Freeman Hospital, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

PMID: 37547751
PMCID: PMC10402633
DOI: 10.3389/ti.2023.11374

European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy

Joana Ferrer-Fàbrega et al. Transpl Int. 2023.

. 2023 Jul 19:36:11374.

doi: 10.3389/ti.2023.11374. eCollection 2023.

Authors

Affiliations

¹ Hepatobiliopancreatic Surgery and Liver and Pancreatic Transplantation Unit, Department of Surgery, Institute Clínic of Digestive and Metabolic Diseases (ICMDiM), Hospital Clínic, University of Barcelona, Barcelona, Spain.
² Hepatic Oncology Unit, Barcelona Clínic Liver Cancer Group (BCLC), Hospital Clínic, Barcelona, Spain.
³ August Pi i Sunyer Biomedical, Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.
⁴ Network for Biomedical Research in Hepatic and Digestive Diseases (CIBEREHD), Barcelona, Spain.
⁵ Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.
⁶ Centre for Research in Transplantation and Translational Immunology, INSERM UMR 1064, ITUN5, Nantes, France.
⁷ Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
⁸ Transplantation Center, Leiden University Medical Center, Leiden, Netherlands.
⁹ Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, United States.
¹⁰ Research Group for Islet Transplantation, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
¹¹ Department of Surgery, University Medical Center Groningen, Groningen, Netherlands.
¹² Transplant Division, Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Sweden.
¹³ Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
¹⁴ Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
¹⁵ Ajmera Transplant Centre, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
¹⁶ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
¹⁷ Division of General Surgery and Transplantation, University of Pisa, Pisa, Italy.
¹⁸ Division of Transplantation, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland.
¹⁹ Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.
²⁰ Department of Surgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
²¹ Department of Nephrology and Transplantation, Guy's Hospital, London, United Kingdom.
²² Department of HPB and Transplant Surgery, NIHR BTRU in Organ Donation and Transplantation, The Freeman Hospital, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

PMID: 37547751
PMCID: PMC10402633
DOI: 10.3389/ti.2023.11374

Abstract

The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidney's and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the "Role of pancreas machine perfusion to increase the donor pool for beta cell replacement," the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague.

Keywords: ischemia-reperfusion injury; islet transplantation; machine perfusion; persufflation; whole pancreas transplantation.

Copyright © 2023 Ferrer-Fàbrega, Mesnard, Messner, Doppenberg, Drachenberg, Engelse, Johnson, Leuvenink, Oniscu, Papalois, Ploeg, Reichman, Scott, Vistoli, Berney, Jacobs-Tulleneers-Thevissen, Kessaris, Weissenbacher, Ogbemudia, White and Branchereau.

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Conflict of interest statement

JF-F received lecture fees from Bayer and AstraZeneca; consultancy fees from AstraZeneca. JF-F is the recipient of a grant supported by Instituto de Salud Carlos III (ISCIII) through the project “PI18/00161 (Optimization of pancreas transplant graft: A multicentric study of histo-morphological and functional characteristics of unaccepted organs.)” and co-funded by the European Union. BM received grand support from Institut Georges Lopez and the Hémarina Society. RP is an advisor to Bridge to Life Ltd. UK for issues on organ preservation. TR received consultancy fees from Sernova Corp and clinical trial support from Vertex Pharmaceuticals. WS is the co-founder and Chief Scientific Officer of ScubaTx Ltd. JB received logistic help/research grant from Institute Georges Lopez, Organ Revovery System, Hemarina, Bridge to life, and Xvivo. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**FIGURE 1**
PRISMA Flowchart: Literature search.

See this image and copyright information in PMC

References

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European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy

Affiliations

European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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MeSH terms

LinkOut - more resources

Full Text Sources

Medical