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. 2023 Aug;53(8):1481-1484.
doi: 10.1111/imj.16197. Epub 2023 Aug 7.

Proton pump inhibitors and the risk of acquiring a penicillin allergy label

Sarah Al-Obaydi  1 , Catherine A Popadiuk  2 , Taha Al-Shaikhly  2
Affiliations

Proton pump inhibitors and the risk of acquiring a penicillin allergy label

Sarah Al-Obaydi et al. Intern Med J. 2023 Aug.

Abstract

The negative consequences of having a penicillin allergy label are well established. Penicillin allergy de-labelling improves healthcare outcomes; however, less attention is paid to modifying risk factors leading to penicillin allergy development. In this propensity score-matched retrospective cohort study, we used a de-identified population-based database (TriNetX Research Network) and examined the 30-day risk of acquiring a penicillin allergy label in patients using proton pump inhibitors (PPIs). We demonstrated a higher risk of acquiring a penicillin allergy label among PPI users compared to controls.

Keywords: PPI; drug allergy; gastric acid suppression; penicillin allergy label; proton pump inhibitors.

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Conflict of interest statement

Conflicts of interest: All authors have no conflicts of interest to disclose.

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