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. 2023 Aug 7;408(1):297.
doi: 10.1007/s00423-023-03025-w.

Spleen volume is a predictor of posthepatectomy liver failure and short-term mortality for hepatocellular carcinoma

Takahiro Ito  1 , Akihiro Tanemura  2 , Toru Kuramitsu  2 , Taichi Murase  2 , Benson Kaluba  2 , Daisuke Noguchi  2 , Tekehiro Fujii  2 , Takuya Yuge  2 , Koki Maeda  2 , Aoi Hayasaki  2 , Kazuyuki Gyoten  2 , Yusuke Iizawa  2 , Yasuhiro Murata  2 , Naohisa Kuriyama  2 , Masashi Kishiwada  2 , Shugo Mizuno  2
Affiliations

Spleen volume is a predictor of posthepatectomy liver failure and short-term mortality for hepatocellular carcinoma

Takahiro Ito et al. Langenbecks Arch Surg. .

Abstract

Background: The study aimed at retrospectively assessing the impact of spleen volume (SpV) on the development of posthepatectomy liver failure (PHLF) in patients who underwent hepatectomy for hepatocellular carcinoma (HCC).

Methods: 152 patients with primary HCC who underwent hepatectomy (sectionectomy or more) were classified into PHLF and non-PHLF groups, and then the relationship between PHLF and SpV was assessed. SpV (cm3) was obtained from preoperative CT and standardized based on the patient's body surface area (BSA, m2).

Results: PHLF was observed in 39 (26%) of the 152 cases. SpV/BSA was significantly higher in the PHLF group, and the postoperative 1-year survival rate was significantly worse in the PHLF group than that in the non-PHLF group (p = 0.044). Multivariable analysis revealed SpV/BSA as a significant independent risk factor for PHLF. Using the cut-off value (160 cm3/m2), the 152 cases were divided into small SpV and large SpV groups. The incidence of PHLF was significantly higher in the large SpV group (p = 0.002), the liver failure-related mortality rate was also significantly higher in the large SpV group (p = 0.007), and the 1-year survival rate was significantly worse in the large SpV group (p = 0.035).

Conclusion: These results suggest SpV as a predictor of PHLF and short-term mortality in patients who underwent hepatectomy for HCC. Moreover, SpV measurement is a simple and potentially useful method for predicting PHLF in patients with HCC.

Keywords: Hepatectomy; Liver cirrhosis; Portal hypertension; Posthepatectomy liver failure; Spleen volume.

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