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Meta-Analysis
. 2023 Aug 7;18(1):108.
doi: 10.1007/s11657-023-01317-8.

Effects of exercise on bone mineral density in middle-aged and older men: A comprehensive meta-analysis

Xiaoqin Lu  1 , Jiapei Wei  1 , Yupeng Liu  2 , Yangzhen Lu  3
Affiliations
Meta-Analysis

Effects of exercise on bone mineral density in middle-aged and older men: A comprehensive meta-analysis

Xiaoqin Lu et al. Arch Osteoporos. .

Abstract

This meta-analysis including 10 randomised controlled trials suggests that exercise is associated with a statistically significant, but relatively mild, improvement effect on bone mineral density in middle-aged and older men, indicating that exercise has the potential to be a safe and effective way toavert bone loss in men.

Purpose: To determine the effect of exercise on bone mineral density (BMD) in middle-aged and older men.

Methods: We searched three electronic databases up to March 21, 2022. A systematic review of the literature according to the PRISMA statement included (1) randomised controlled trials (RCTs), with (2) at least one exercise group as an intervention versus a control group, (3) men aged ≥ 45 years old, and (4) areal BMD of the lumbar spine (LS) and/or femoral neck (FN) and/or total hip (TH) and/or trochanter region. Mean differences (MD) for BMD changes at the LS, FN, TH, and trochanter were defined as outcome measures.

Results: A total of 10 eligible RCTs were included (N = 555 participants). Exercise significantly improved BMD, and the summarised MD was 0.02 (95% CI: 0.00 to 0.05) for LS BMD, 0.01 (95% CI: 0.00 to 0.02) for FN BMD, 0.01 (95% CI: 0.00 to 0.01) for TH BMD, and 0.03 (95% CI: 0.00 to 0.05) for trochanter BMD. Subgoup analyses showed the improvement effect was statistically significant in trials with longer duration and higher intensity in LS (≥ 12 months: MD, 0.01, 95% CI:0.00 to 0.03; higher intensity: MD, 0.01, 95% CI:0.00 to 0.03) and FN (≥ 12 months: MD, 0.02, 95% CI:0.01 to 0.02; higher intensity: MD, 0.01, 95% CI:0.01 to 0.02).

Conclusion: Our results suggested a relatively mild, improvement effect of exercise on LS and proximal femur BMD. Exercise has the potential to be an effective way to avert bone loss in middle-aged and older men.

Keywords: Bone mineral density; Exercise; Men; Osteoporosis.

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References

    1. Kanis JA, Cooper C, Rizzoli R, Reginster JY (2019) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 30(1):3–44. https://doi.org/10.1007/s00198-018-4704-5 - DOI - PubMed
    1. Lötters FJ, van den Bergh JP, de Vries F, Rutten-van Mölken MP (2016) Current and Future Incidence and Costs of Osteoporosis-Related Fractures in The Netherlands: Combining Claims Data with BMD Measurements. Calcif Tissue Int 98(3):235–243. https://doi.org/10.1007/s00223-015-0089-z - DOI - PubMed - PMC
    1. Noel SE, Santos MP, Wright NC (2021) Racial and Ethnic Disparities in Bone Health and Outcomes in the United States. J Bone Miner Res 36(10):1881–1905. https://doi.org/10.1002/jbmr.4417 - DOI - PubMed
    1. Wright NC, Looker AC, Saag KG, Curtis JR, Delzell ES, Randall S, Dawson-Hughes B (2014) The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res 29(11):2520–2526. https://doi.org/10.1002/jbmr.2269 - DOI - PubMed
    1. Singer A, Exuzides A, Spangler L, O’Malley C, Colby C, Johnston K, Agodoa I, Baker J, Kagan R (2015) Burden of illness for osteoporotic fractures compared with other serious diseases among postmenopausal women in the United States. Mayo Clin Proc 90(1):53–62. https://doi.org/10.1016/j.mayocp.2014.09.011 - DOI - PubMed

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