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. 2024 Feb;23(1):87-101.
doi: 10.1007/s10237-023-01760-z. Epub 2023 Aug 7.

Pathogenic mechanism analysis of cochlear key structural lesion and phonosensitive hearing loss

Junyi Liang  1 , Jiakun Wang  2   3 , Mianzhi Wang  2   3 , Wenjuan Yao  4   5
Affiliations

Pathogenic mechanism analysis of cochlear key structural lesion and phonosensitive hearing loss

Junyi Liang et al. Biomech Model Mechanobiol. 2024 Feb.

Abstract

Due to ethical issues and the very fine and complex structure of the cochlea, it is difficult to directly perform experimental measurement on the human cochlea. Therefore, the finite element method has become an effective and replaceable new research means. Accurate numerical analysis on human ear using finite element method can provide better understanding of sound transmission and can be used to assess the influence of diseases on hearing and to treat hearing loss. In this research, a three-dimensional (3D) finite element model (FEM) of the human ear of cochlea was presented to investigate the destruction of basilar membrane (BM), round window (RW) sclerosis and perilymph fistula, the key structures of the cochlea, and analyze the effects of these abnormal pathological states in the cochlea on cochlear hearing, resulting in the changes in cochlear sense structure biomechanical behavior and quantitative prediction of the degree and harm of the disorder to the decline of human hearing. Therefore, this paper can deepen reader's understanding of the cochlear biomechanical mechanism and provide a theoretical foundation for clinical otology.

Keywords: BM's destruction; Cochlea; FEM; Hearing loss; Perilymph fistula; RW sclerosis.

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