Disease Clearance as a New Outcome in Ulcerative Colitis: a Systematic Review and Expert Consensus

Ferdinando D'Amico^{1

2}, Fernando Magro³, Britta Siegmund⁴, Taku Kobayashi⁵, Paulo Gustavo Kotze⁶, Virginia Solitano^{2

7}, Benedicte Caron^{8

9}, Sameer Al Awadhi¹⁰, Ailsa Hart¹¹, Vipul Jairath⁷, Axel Dignass¹², Laurent Peyrin-Biroulet^{8

9}, Silvio Danese¹

Affiliations

¹ Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.
² Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
³ Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of the University of Porto, Porto, Portugal.
⁴ Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
⁵ Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
⁶ Colorectal Surgery Unit, Hospital Universitário Cajuru, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Brazil.
⁷ Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
⁸ University of Lorraine, CHRU-Nancy, Department of Gastroenterology, F-54000 Nancy, France.
⁹ University of Lorraine, Inserm, NGERE, F-54000 Nancy, France.
¹⁰ Digestive Diseases Unit, Rashid Hospital, Dubai 003206, United Arab Emirates.
¹¹ St Mark's Hospital, Harrow, Middlesex, UK.
¹² Department of Medicine I, Agaplesion Markus Hospital, Goethe-University, Frankfurt am Main, Germany.

PMID: 37549104
DOI: 10.1093/ibd/izad159

Disease Clearance as a New Outcome in Ulcerative Colitis: a Systematic Review and Expert Consensus

Ferdinando D'Amico et al. Inflamm Bowel Dis. 2024.

. 2024 Jun 3;30(6):1009-1017.

doi: 10.1093/ibd/izad159.

Authors

Affiliations

¹ Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.
² Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
³ Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of the University of Porto, Porto, Portugal.
⁴ Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
⁵ Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
⁶ Colorectal Surgery Unit, Hospital Universitário Cajuru, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Brazil.
⁷ Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
⁸ University of Lorraine, CHRU-Nancy, Department of Gastroenterology, F-54000 Nancy, France.
⁹ University of Lorraine, Inserm, NGERE, F-54000 Nancy, France.
¹⁰ Digestive Diseases Unit, Rashid Hospital, Dubai 003206, United Arab Emirates.
¹¹ St Mark's Hospital, Harrow, Middlesex, UK.
¹² Department of Medicine I, Agaplesion Markus Hospital, Goethe-University, Frankfurt am Main, Germany.

PMID: 37549104
DOI: 10.1093/ibd/izad159

Abstract

The concept of disease clearance has been proposed as a potential target in ulcerative colitis (UC). We conducted a systematic review to investigate the role of disease clearance, defined as a composite outcome including simultaneous clinical, endoscopic, and histologic remission of disease in the management of patients with UC. Based on the literature data, statements regarding disease clearance were developed and voted on by the members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) according to a Delphi methodology. A definition of disease clearance was proposed to standardize its use in clinical practice and clinical trials and to provide practical recommendations for its implementation as a therapeutic target in UC.

Keywords: deep remission; disease clearance; inflammatory bowel disease; ulcerative colitis.

© The Author(s) 2023. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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Comment in

Disease Clearance is not Synonymous with Cure.
D'Amico F, Peyrin-Biroulet L, Danese S. D'Amico F, et al. Inflamm Bowel Dis. 2024 Mar 1;30(3):509. doi: 10.1093/ibd/izad236. Inflamm Bowel Dis. 2024. PMID: 37796102 No abstract available.
Is Ulcerative Colitis Really Ever "Cleared?".
Rao V, Cockburn E, Segal JP. Rao V, et al. Inflamm Bowel Dis. 2024 Jun 3;30(6):1049. doi: 10.1093/ibd/izad234. Inflamm Bowel Dis. 2024. PMID: 37797276 No abstract available.

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Disease Clearance as a New Outcome in Ulcerative Colitis: a Systematic Review and Expert Consensus

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Disease Clearance as a New Outcome in Ulcerative Colitis: a Systematic Review and Expert Consensus

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Abstract

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