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. 2023 Nov 1;208(9):915-916.
doi: 10.1164/rccm.202307-1200VP.

Affordable Cystic Fibrosis (CF) Transmembrane Conductance Regulator Modulator Drugs for CF: All CF Lives Worldwide Matter!

Marco Zampoli  1 , Janine Verstraete  1 , Cathy Baird  2 , Greg Calligaro  3 , Brenda Morrow  1
Affiliations

Affordable Cystic Fibrosis (CF) Transmembrane Conductance Regulator Modulator Drugs for CF: All CF Lives Worldwide Matter!

Marco Zampoli et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Baseline and change in sweat chloride (A) and FEV1% predicted (B) in people with cystic fibrosis who initiated treatment with generic elexacaftor/tezacaftor/ivacaftor on a standard, modulator-sparing, or a combination of dosing strategies. Markers indicate mean values and vertical bars 95% confidence intervals.
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References

    1. King JA, Nichols AL, Bentley S, Carr SB, Davies JC. An update on CFTR modulators as new therapies for cystic fibrosis. Paediatr Drugs . 2022;24:321–333. - PubMed
    1. Zampoli M, Morrow BM, Paul G. Real-world disparities and ethical considerations with access to CFTR modulator drugs: mind the gap! Front Pharmacol . 2023;14:1163391. - PMC - PubMed
    1. McGarry ME, Gibb ER, Laguna TA, O’Sullivan BP, Sawicki GS, Zobell JT. How many billions is enough? Prioritizing profits over patients with cystic fibrosis. Pediatr Pulmonol . 2023;58:1595–1597. - PMC - PubMed
    1. Guo J, Wang J, Zhang J, Fortunak J, Hill A. Current prices versus minimum costs of production for CFTR modulators. J Cyst Fibros . 2022;21:866–872. - PubMed
    1. Robbins SNR.Miracle cystic fibrosis drug kept out of reach in developing countries. New York Times . 2023.

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