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Review
. 2023 Dec 23;35(12):583-594.
doi: 10.1093/intimm/dxad031.

Follicular regulatory T cell subsets in mice and humans: origins, antigen specificity and function

Sophia Sokolova  1 , Irina L Grigorova  1   2
Affiliations
Review

Follicular regulatory T cell subsets in mice and humans: origins, antigen specificity and function

Sophia Sokolova et al. Int Immunol. .

Abstract

Follicular regulatory T (Tfr) cells play various roles in immune responses, contributing to both positive and negative regulation of foreign antigen-specific B cell responses, control over autoreactive antibody responses and autoimmunity, and B cell class-switching to IgE and allergy development. Studies conducted on mice uncovered various subsets of CXCR5+FoxP3+CD4+ Tfr cells that could differently contribute to immune regulation. Moreover, recent studies of human Tfr cells revealed similar complexity with various subsets of follicular T cells of different origins and immunosuppressive and/or immunostimulatory characteristics. In this review we will overview and compare Tfr subsets currently identified in mice and humans and will discuss their origins and antigen specificity, as well as potential modes of action and contribution to the control of the autoimmune and allergic reactions.

Keywords: IgE; allergy; autoimmune diseases; germinal centers; plasma cells.

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