Association between inflammatory bowel disease and Alzheimer's disease: multivariable and bidirectional Mendelian randomisation analyses

Li Jiang¹, Jin-Chen Li^{1

2

3

4

5

6}, Lu Shen^{1

2

3

4

5

6}, Bei-Sha Tang^{1

2

3

4

5

6}, Ji-Feng Guo^{7

2

3

4

5

6}

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China.
³ Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, Hunan, China.
⁴ Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
⁵ Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, Hunan, China.
⁶ Bioinformatics Center && National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁷ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China guojifeng2003@163.com.

Comment

Li Jiang et al. Gut. 2023 Sep.

. 2023 Sep;72(9):1797-1799.

doi: 10.1136/gutjnl-2022-327860. Epub 2022 Sep 8.

Li Jiang¹, Jin-Chen Li^{1

2

3

4

5

6}, Lu Shen^{1

2

3

4

5

6}, Bei-Sha Tang^{1

2

3

4

5

6}, Ji-Feng Guo^{7

2

3

4

5

6}

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China.
³ Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, Hunan, China.
⁴ Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
⁵ Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, Hunan, China.
⁶ Bioinformatics Center && National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁷ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China guojifeng2003@163.com.

No abstract available

Keywords: EPIDEMIOLOGY; GENETICS; INFLAMMATORY BOWEL DISEASE; NERVE - GUT INTERACTIONS.

Conflict of interest statement

Competing interests: None declared.

Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study.
Zhang B, Wang HE, Bai YM, Tsai SJ, Su TP, Chen TJ, Wang YP, Chen MH. Zhang B, et al. Gut. 2021 Jan;70(1):85-91. doi: 10.1136/gutjnl-2020-320789. Epub 2020 Jun 23. Gut. 2021. PMID: 32576641