Gamma oscillations and episodic memory

Abstract

Enhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence reviewed, we propose that multiple, distinct forms of gamma oscillation can be found within the canonical gamma band, each of which has a complementary role in the neural processes listed above. Further exploration of these theories using causal manipulations may be key to elucidating the relevance of gamma oscillatory activity to episodic memory.

Keywords: electrophysiology; episodic memory; neural communication; neural oscillations; sequence learning; synaptic plasticity.