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. 2023 Aug 7;23(1):388.
doi: 10.1186/s12887-023-04208-6.

Burden of human metapneumovirus infections among children with acute respiratory tract infections attending a Tertiary Care Hospital, Kathmandu

Jyoti Lamichhane #  1 , Milan Upreti #  1 , Krishus Nepal  1 , Bishnu Prasad Upadhyay  2 , Urusha Maharjan  2 , Ram Krishna Shrestha  2 , Ram Hari Chapagain  3 , Megha Raj Banjara  4 , Upendra Thapa Shrestha  5
Affiliations

Burden of human metapneumovirus infections among children with acute respiratory tract infections attending a Tertiary Care Hospital, Kathmandu

Jyoti Lamichhane et al. BMC Pediatr. .

Abstract

Background: Acute respiratory infections (ARIs) are one of the most common causes of mortality and morbidity worldwide. Every year millions of children suffer from viral respiratory tract infections (RTIs) ranging from mild to severe illnesses. Human Metapneumovirus (HMPV) is among the most frequent viruses responsible for RTIs. However, HMPV infections and their severity among children have not been explored yet in Nepal.

Purpose: Therefore, the study was focused on HMPV infections and other potential viral etiologies or co-infections using multiplex PCR among children attending Kanti Children's Hospital and assessed the clinical characteristics of the infections as well as found the co-infections. A hospital-based cross-sectional study was designed and a convenience sampling method was used to enroll children of less than 15 years with flu-like symptoms from both outpatients and inpatients departments over three months of the study period.

Results: HMPV infection (13.3%) was the most predominant infection among the different viral infections in children with ARIs in Kanti Children's Hospital. The HMPV was more prevalent in the age group less than three years (21.8%). Cough and fever were the most common clinical features present in all children infected with HMPV followed by rhinorrhea, sore throat, and wheezing. HMPV-positive children were diagnosed with pneumonia (42.9%), bronchiolitis (28.5%), upper respiratory tract infections (14.3%), and asthma (14.3%). The prevalence of HMPV was high in late winter (14.3%) followed by early spring (13.5%).

Conclusions: This study provides the baseline information on HMPV and associated co-infection with other respiratory viruses for the differential diagnosis based on molecular methods and also the comparison of clinical presentations among the different respiratory syndromes.

Keywords: Bronchiolitis; Human metapneumovirus; Multiplex real-time RT-PCR; Pneumonia; Respiratory tract infections.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Month-wise distribution of HMPV infection among suspected children
See this image and copyright information in PMC

References

    1. Bénet T, Sánchez Picot V, Messaoudi M, Chou M, Eap T, Wang J, Shen K, Pape JW, Rouzier V, Awasthi S, Pandey N, Bavdekar A, Sanghavi S, Robinson A, Rakoto-Andrianarivelo M, Sylla M, Diallo S, Nymadawa P, Naranbat N, Russomando G, Basualdo W, Komurian-Pradel F, Endtz H, Vanhems P, Paranhos-Baccalà G. Global Approach to Biological Research, infectious diseases and epidemics in low-income countries (GABRIEL) network; Global Approach to Biological Research, infectious diseases and epidemics in low-income countries (GABRIEL) network. Microorganisms Associated with Pneumonia in Children < 5 years of age in developing and emerging countries: the GABRIEL Pneumonia Multicenter, prospective, case-control study. Clin Infect Dis. 2017;65(4):604–12. - PMC - PubMed
    1. Pneumonia Etiology Research for Child Health Study Group Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study. Lancet. 2019;394(10200):757–79. - PMC - PubMed
    1. Simones EAF, Cherian T, Chow J, Shahid-Salles SA, Laxminarayan R, John TJ, Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P, editors. Acute Respiratory Infections in Children. Disease Control Priorities in Developing Countries. 2nd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank. 2006. Chapter 25. PMID: 21250360.
    1. Jin X, Ren J, Li R, Gao Y, Zhang H, Li J, Zhang J, Wang X, Wang G. Global burden of upper respiratory infections in 204 countries and territories, from 1990 to 2019. E Clin Med. 2021;37:100986. - PMC - PubMed
    1. Kumar SG, Majumdar A, Kumar V, Naik BN, Selvaraj K, Balajee K. Prevalence of acute respiratory infection among under-five children in urban and rural areas of Puducherry, India. J Nat Sci Biology Med. 2015;6(1):3–6. - PMC - PubMed

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