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Review
. 2023 Aug 7;28(1):268.
doi: 10.1186/s40001-023-01244-x.

A review of the application of mesenchymal stem cells in the field of hematopoietic stem cell transplantation

Ting Lin  1 , Yunfan Yang  1 , Xinchuan Chen  2
Affiliations
Review

A review of the application of mesenchymal stem cells in the field of hematopoietic stem cell transplantation

Ting Lin et al. Eur J Med Res. .

Abstract

Hematopoietic stem cell transplantation (HSCT) is an effective treatment for many malignant hematological diseases. Mesenchymal stem cells (MSCs) are nonhematopoietic stem cells with strong self-renewal ability and multidirectional differentiation potential. They have the characteristics of hematopoietic support, immune regulation, tissue repair and regeneration, and homing. Recent studies have shown that HSCT combined with MSC infusion can promote the implantation of hematopoietic stem cells and enhance the reconstruction of hematopoietic function. Researchers have also found that MSCs have good preventive and therapeutic effects on acute and chronic graft-versus-host disease (GVHD), but there is still a lack of validation in large-sample randomized controlled trials. When using MSCs clinically, it is necessary to consider their dose, source, application time, application frequency and other relevant factors, but the specific impact of the above factors on the efficacy of MSCs still needs further clinical trial research. This review introduces the clinical roles of MSCs and summarizes the most recent progress concerning the use of MSCs in the field of HSCT, providing references for the later application of the combination of MSCs and HSCT in hematological diseases.

Keywords: Graft-versus-host disease; Hematological disease; Hematopoietic stem cell transplantation; Mesenchymal stem cell.

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Conflict of interest statement

None of the authors has a potential conflict of interest to disclose.

Figures

Fig. 1
Fig. 1
The sources of MSCs are diverse. MSCs can be isolated from tissues, MSC-like cells and cells able to convert to MSCs
Fig. 2
Fig. 2
The multidirectional differentiation potential of MSCs. MSCs can differentiate into tissues such as bone, cartilage, and adipose tissue, as well as other mesoderm tissues
Fig. 3
Fig. 3
The effects of MSCs on various blood cells
See this image and copyright information in PMC

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