Eosinophilic allergic rhinitis is strongly associated with the CD45RB^lo subset of CD161⁺ Th2 cells that secretes IL-2, IL-3, IL-4, IL-5, IL-9, and IL-13

Wendy W L Lee¹, Kia Joo Puan^{1

2}, Bernett Lee^{1

3}, Celine Chua¹, Ser Mei Koh¹, Nurhashikin Yusof¹, Kim Peng Tan¹, Boris San Luis^{1

4}, Jocelyn Ong¹, Simon Kebede Merid⁵, Rachel Ang¹, Xue Ying Chan¹, Low Jing Hui¹, Elisa Terenzani¹, Josephine Lum¹, Shihui Foo¹, Francesca Zolezzi¹, Annabelle Tay Sok Yan^{6

7}, Erik Melen^{5

8}, Soh Jian Yi⁹, Olaf Rotzschke¹, Anand Kumar Andiappan¹

Affiliations

¹ Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
² Shanghai Junshi Biosciences Co Ltd, Shanghai, China.
³ Centre for Biomedical Informatics, Nanyang Technological University, Singapore, Singapore.
⁴ Institute of Molecular and Cell Biology (IMCB) A*STAR, Proteos, Singapore, Singapore.
⁵ Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁶ Department of Otolaryngology, National University Hospital, Singapore, Singapore.
⁷ Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁸ Department of Paediatrics, Sachs' Children's Hospital, Stockholm, Sweden.
⁹ Department of Paediatrics, National University Hospital, Singapore, Singapore.

Wendy W L Lee et al. Allergy. 2023 Oct.

. 2023 Oct;78(10):2794-2798.

doi: 10.1111/all.15846. Epub 2023 Aug 7.

¹ Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
² Shanghai Junshi Biosciences Co Ltd, Shanghai, China.
³ Centre for Biomedical Informatics, Nanyang Technological University, Singapore, Singapore.
⁴ Institute of Molecular and Cell Biology (IMCB) A*STAR, Proteos, Singapore, Singapore.
⁵ Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁶ Department of Otolaryngology, National University Hospital, Singapore, Singapore.
⁷ Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁸ Department of Paediatrics, Sachs' Children's Hospital, Stockholm, Sweden.
⁹ Department of Paediatrics, National University Hospital, Singapore, Singapore.

No abstract available

References

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1. Mitson-Salazar A, Yin Y, Wansley DL, et al. Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function. J Allergy Clin Immunol. 2016;137(3):907-18 e9.
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