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. 2023 Sep;239(1):e14024.
doi: 10.1111/apha.14024. Epub 2023 Aug 8.

Sex-related differences in motor unit behavior are influenced by myosin heavy chain during high- but not moderate-intensity contractions

Alex A Olmos  1 , Adam J Sterczala  2 , Mandy E Parra  3 , Hannah L Dimmick  4 , Jonathan D Miller  5 , Jake A Deckert  6 , Stephanie A Sontag  1 , Philip M Gallagher  7 , Andrew C Fry  8 , Trent J Herda  9 , Michael A Trevino  1
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Sex-related differences in motor unit behavior are influenced by myosin heavy chain during high- but not moderate-intensity contractions

Alex A Olmos et al. Acta Physiol (Oxf). 2023 Sep.

Abstract

Aims: Motor unit recruitment and firing rate patterns of the vastus lateralis (VL) have not been compared between sexes during moderate- and high-intensity contraction intensities. Additionally, the influence of fiber composition on potential sex-related differences remains unquantified.

Methods: Eleven males and 11 females performed 40% and 70% maximal voluntary contractions (MVCs). Surface electromyographic (EMG) signals recorded from the VL were decomposed. Recruitment thresholds (RTs), MU action potential amplitudes (MUAPAMP ), initial firing rates (IFRs), mean firing rates (MFRs), and normalized EMG amplitude (N-EMGRMS ) at steady torque were analyzed. Y-intercepts and slopes were calculated for MUAPAMP , IFR, and MFR versus RT relationships. Type I myosin heavy chain isoform (MHC) was determined with muscle biopsies.

Results: There were no sex-related differences in MU characteristics at 40% MVC. At 70% MVC, males exhibited greater slopes (p = 0.002) for the MUAPAMP , whereas females displayed greater slopes (p = 0.001-0.007) for the IFR and MFR versus RT relationships. N-EMGRMS at 70% MVC was greater for females (p < 0.001). Type I %MHC was greater for females (p = 0.006), and was correlated (p = 0.018-0.031) with the slopes for the MUAPAMP , IFR, and MFR versus RT relationships at 70% MVC (r = -0.599-0.585).

Conclusion: Both sexes exhibited an inverse relationship between MU firing rates and recruitment thresholds. However, the sex-related differences in MU recruitment and firing rate patterns and N-EMGRMS at 70% MVC were likely due to greater type I% MHC and smaller twitch forces of the higher threshold MUs for the females. Evidence is provided that muscle fiber composition may explain divergent MU behavior between sexes.

Keywords: motor unit; myosin heavy chain; sex differences; vastus lateralis.

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