When Stress Is Not the Only Culprit: A Case of Secondary Adrenal Insufficiency in a Young Patient With Graves' Disease
- PMID: 37551210
- PMCID: PMC10404451
- DOI: 10.7759/cureus.41528
When Stress Is Not the Only Culprit: A Case of Secondary Adrenal Insufficiency in a Young Patient With Graves' Disease
Abstract
This case report underscores the significance of maintaining a broad list of differential diagnoses, including adrenal insufficiency, when evaluating patients who present with recurring episodes of hypotension and generalized fatigue. It further underscores that T3 thyrotoxicosis can manifest as the initial and sole presenting feature of Graves' disease. Finally, it emphasizes the critical importance of employing a multidisciplinary approach to discharge high-risk patients from the hospital to minimize the risk of acute decompensation.
Keywords: addisonian crisis; graves' disease; hypotension; secondary adrenal insufficiency; t3-thyrotoxicosis.
Copyright © 2023, Ozair et al.
Conflict of interest statement
The authors have declared that no competing interests exist.
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References
-
- Secondary adrenal insufficiency: recent updates and new directions for diagnosis and management. Gruber LM, Bancos I. Endocr Pract. 2022;28:110–117. - PubMed
-
- Clinical presentation and outcomes of opioid-induced adrenal insufficiency. Li T, Donegan D, Hooten WM, Bancos I. Endocr Pract. 2020;26:1291–1297. - PubMed
-
- Case report of a primary pituitary abscess and systematic literature review of pituitary abscess with a focus on patient outcomes. Agyei JO, Lipinski LJ, Leonardo J. World Neurosurg. 2017;101:76–92. - PubMed
-
- Adrenal insufficiency: physiology, clinical presentation and diagnostic challenges. Martin-Grace J, Dineen R, Sherlock M, Thompson CJ. Clin Chim Acta. 2020;505:78–91. - PubMed
-
- Secondary adrenal insufficiency: from the physiopathology to the possible role of modified-release hydrocortisone treatment. Paragliola RM, Corsello SM. Minerva Endocrinol. 2018;43:183–197. - PubMed
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