[The Latest Research Progress of Mesenchymal Stem Cells Derived from Multiple Myeloma Patients --Review]
- PMID: 37551504
- DOI: 10.19746/j.cnki.issn.1009-2137.2023.04.047
[The Latest Research Progress of Mesenchymal Stem Cells Derived from Multiple Myeloma Patients --Review]
Abstract
Multiple myeloma (MM) is a malignant proliferative disease of plasma cells. Bone marrow mesenchymal stem cells (MSC) play an important role in the progression of MM. Compared with normal donor derived MSC (ND-MSC), MM patients derived MSC (MM-MSC) exhibit abnormalities in genes, signaling pathways, protein expression levels and cytokines secreted by themselves. Moreover, the exosomes of MM-MSC can interact with the bone marrow microenvironment. The above reasons can lead to MM cell proliferation, chemoresistance, impaired osteogenic differentiation of MM-MSC, and affect the immunomodulatory capacity of MM patients. In order to further understand the pathogenesis and related influencing factors of MM, this paper reviews the latest research progress of MM-MSC.
题目: 多发性骨髓瘤患者来源间充质干细胞的最新研究进展.
摘要: .多发性骨髓瘤（MM）是一种浆细胞恶性增殖性疾病，骨髓间充质干细胞（MSC）在MM的疾病进展过程中发挥着重要作用。与正常供者来源MSC（ND-MSC）相比，MM来源MSC（MM-MSC）表现出基因、信号通路、蛋白质表达水平和自身分泌细胞因子的异常，且其外泌体与骨髓微环境相互影响，以上原因可导致MM细胞增殖、化疗耐药、MM-MSC成骨分化障碍，并影响MM患者的免疫调节能力。为进一步了解MM的发病机理及相关影响因素，本文针对MM-MSC的最新研究进展作一综述。.
Keywords: bone marrow microenvironment; cytokines; mesenchymal stem cells; multiple myeloma; signaling pathways.
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