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Review
. 2024 Jan;76(1):1-8.
doi: 10.1002/art.42671. Epub 2023 Oct 16.

Complement

Paul A Monach  1
Affiliations
Review

Complement

Paul A Monach. Arthritis Rheumatol. 2024 Jan.

Abstract

The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis. The review includes a discussion of complement deficiency states, consumption of complement by diseases characterized by immune-complex formation and deposition, usefulness and interpretation of laboratory tests for complement, and development of drugs targeting specific components of the complement pathway for a growing number of indications.

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References

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