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Meta-Analysis
. 2023 Dec;20(10):4077-4082.
doi: 10.1111/iwj.14299. Epub 2023 Aug 9.

Association between diabetic retinopathy and diabetic foot ulcer in patients with diabetes: A meta-analysis

Ziye Li  1 , Jing Wei  1 , Song Lu  1
Affiliations
Meta-Analysis

Association between diabetic retinopathy and diabetic foot ulcer in patients with diabetes: A meta-analysis

Ziye Li et al. Int Wound J. 2023 Dec.

Retraction in

Abstract

This study aimed to explore the relationship between diabetic retinopathy (DR) and diabetic foot ulcers (DFUs) to provide evidence for the prevention of diabetic complications. PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Chinese Biomedical Literature Database and Wanfang Data databases were searched from their inception until March 2023 for studies on the relationship between DR and DFU. Two researchers independently screened the literature and extracted data according to the inclusion and exclusion criteria. The meta-analysis was performed using the RevMan 5.3 software. Eleven articles referring to 10 208 patients were included, of whom 2191 patients had DFU and 8017 patients did not have DFU. The meta-analysis results showed that DR significantly increased the incidence of DFU (47.94% vs. 16.38%; OR, 4.13; 95% CI, 2.33-7.33; p < 0.001). The results of this study suggest that patients with DR have a higher risk of developing DFU, highlighting the importance of regular screening for these two complications to prevent serious adverse outcomes of diabetes. However, further high-quality studies are required to validate the conclusions of the present study.

Keywords: complication; diabetic foot ulcers; diabetic retinopathy; meta-analysis.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flow chart of the studies included in meta‐analysis.
FIGURE 2
FIGURE 2
The forest plot of the relationship between diabetic retinopathy and diabetic foot ulcers.
FIGURE 3
FIGURE 3
Funnel plot for publication bias.
See this image and copyright information in PMC

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References

    1. Gonçalves MG, Medeiros MA, de Lemos LIC, et al. Effects of creatine supplementation on histopathological and biochemical parameters in the kidney and pancreas of streptozotocin‐induced diabetic rats. Nutrients. 2022;14(3):431. - PMC - PubMed
    1. Cho NH, Shaw J, Karuranga S, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271‐281. - PubMed
    1. Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas. Diabetes Res Clin Pract. 2019;157:107843. - PubMed
    1. Vangeepuram N, Liu B, Chiu PH, Wang L, Pandey G. Predicting youth diabetes risk using NHANES data and machine learning. Sci Rep. 2021;11(1):11212. - PMC - PubMed
    1. Jia Z, Liu L, Zhang S, et al. Proteomics changes after negative pressure wound therapy in diabetic foot ulcers. Mol Med Rep. 2021;24(6):834. - PMC - PubMed