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Review
. 2023 Jul 24:11:1166308.
doi: 10.3389/fcell.2023.1166308. eCollection 2023.

Role of TNF-α-induced m6A RNA methylation in diseases: a comprehensive review

Youlin Wang  1 , Jing Liu  1 , Yongchen Wang  1   2
Affiliations
Review

Role of TNF-α-induced m6A RNA methylation in diseases: a comprehensive review

Youlin Wang et al. Front Cell Dev Biol. .

Abstract

Tumor Necrosis Factor-alpha (TNF-α) is ubiquitous in the human body and plays a significant role in various physiological and pathological processes. However, TNF-α-induced diseases remain poorly understood with limited efficacy due to the intricate nature of their mechanisms. N6-methyladenosine (m6A) methylation, a prevalent type of epigenetic modification of mRNA, primarily occurs at the post-transcriptional level and is involved in intranuclear and extranuclear mRNA metabolism. Evidence suggests that m6A methylation participates in TNF-α-induced diseases and signaling pathways associated with TNF-α. This review summarizes the involvement of TNF-α and m6A methylation regulators in various diseases, investigates the impact of m6A methylation on TNF-α-induced diseases, and puts forth potential therapeutic targets for treating TNF-α-induced diseases.

Keywords: N6-methyladenosine (m6A); TNF-α; autoimmune disease; immunity; signaling pathway.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The role of TNF-α in TNF-α-induced diseases. Macrophages, neutrophils, and T cells secrete TNF-α. TNF-α promotes inflammatory cell activation and accumulation induces inflammatory factor production, forms a local inflammatory environment, and leads to tissue proliferation and destruction.
FIGURE 2
FIGURE 2
The role of m6A in TNF-α-medicated diseases. m6A regulator levels (writers, erasers, and readers) change upon TNF-α stimulation. Simultaneously, TNF-α levels change with altered m6A regulator expressions, implying that TNF-α and m6A regulators interact with each other and jointly impact the disease condition. However, the causal relationship between TNF-α and m6A regulators is currently unknown.
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