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. 2023 Jul 25:37:100849.
doi: 10.1016/j.lanwpc.2023.100849. eCollection 2023 Aug.

Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore

Rachael Pung  1   2 , Xin Peng Kong  1 , Lin Cui  3 , Sae-Rom Chae  1   3 , Mark I-Cheng Chen  1   3 , Vernon J Lee  1   3   4 , Zheng Jie Marc Ho  1   4
Affiliations

Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore

Rachael Pung et al. Lancet Reg Health West Pac. .

Abstract

Several XBB subvariants such as XBB.1.5, XBB.1.9, XBB.1.16 and XBB.2.3 co-circulate in Singapore. Despite the different viral properties of XBB.1.16 as compared to other XBB subvariants, comparison on their severity is limited. In this study, we investigate the outcomes of hospitalisation and severe COVID-19 infection in individuals infected with different XBB subvariants, adjusted for potential confounders such as age and vaccination history. Overall, our preliminary analysis showed that the risk of severe outcomes when infected with XBB.1.16 is higher than that of XBB.1.5 or XBB.1.9 but there is no difference in the risk of hospitalisation across different XBB subvariants.

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1
Fig. 1
Probability of infection outcomes for different XBB subvariants and vaccination history; (A) severe infection in those aged 60 and above, (B) hospitalisation in those aged 60 and above, (C) severe infection in those aged below 60, (D) hospitalisation in those aged below 60.
See this image and copyright information in PMC

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