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. 2023 Sep;31(9):2218-2228.
doi: 10.1002/oby.23813. Epub 2023 Aug 9.

The long-term effects of childhood adiposity on depression and anxiety in adulthood: A systematic review

Claire Gallagher  1 , Nilakshi Waidyatillake  1   2 , Jane Pirkis  3 , Katrina Lambert  4 , Raisa Cassim  5 , Shyamali Dharmage  1 , Bircan Erbas  4   6
Affiliations

The long-term effects of childhood adiposity on depression and anxiety in adulthood: A systematic review

Claire Gallagher et al. Obesity (Silver Spring). 2023 Sep.

Abstract

Objective: This review aimed to evaluate the association between childhood adiposity and depression and anxiety risk in adulthood.

Methods: MEDLINE, PsychInfo, Embase, CINAHL, and Scopus were searched on June 6, 2022, to identify studies that investigated the association between childhood weight status (age ≤18 years) and outcomes of depression and/or anxiety in adulthood (age ≥19 years). Study quality was assessed using the Newcastle-Ottawa Scale and results were narratively synthesized.

Results: Sixteen studies were eligible for inclusion, with heterogeneity in methods and follow-up durations complicating comparisons. Six out of eight studies found a statistically significant association between childhood adiposity and increased likelihood of depression in adulthood, particularly in females. However, overall evidence was of moderate quality and study limitations prevented causal conclusions. In contrast, limited evidence and mixed findings were reported for the associations between childhood adiposity and depressive symptom severity or anxiety outcomes in adulthood.

Conclusions: Evidence suggests that childhood adiposity is associated with greater vulnerability to depression in adulthood, particularly in females. However, further research is warranted to address the limitations discussed. Future research should also explore how changes in weight status from childhood to adulthood might differentially influence the likelihood of depression.

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References

REFERENCES

    1. Santomauro DF, Mantilla Herrera AM, Shadid J, et al. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet. 2021;398(10312):1700-1712.
    1. Lopresti AL, Hood SD, Drummond PD. A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. J Affect Disord. 2013;148(1):12-27.
    1. Sarris J, O'Neil A, Coulson CE, Schweitzer I, Berk M. Lifestyle medicine for depression. BMC Psychiatry. 2014;14(1):107. doi:10.1186/1471-244X-14-107
    1. Opie RS, O'Neil A, Itsiopoulos C, Jacka FN. The impact of whole-of-diet interventions on depression and anxiety: a systematic review of randomised controlled trials. Public Health Nutr. 2015;18(11):2074-2093.
    1. Gariepy G, Nitka D, Schmitz N. The association between obesity and anxiety disorders in the population: a systematic review and meta-analysis. Int J Obes (Lond). 2010;34(3):407-419.

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