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. 2023 Aug 18;48(6):280-298.
doi: 10.1080/87565641.2023.2239401. Epub 2023 Aug 9.

Longitudinal Predictors of Neurodevelopmental Outcomes in Children with Down Syndrome

Deborah J Fidler  1 , Kaylyn Van Deusen  1 , Mark A Prince  2 , Emily K Schworer  3 , Nancy R Lee  4 , Jamie O Edgin  5 , Lina R Patel  6 , Lisa A Daunhauer  1
Affiliations

Longitudinal Predictors of Neurodevelopmental Outcomes in Children with Down Syndrome

Deborah J Fidler et al. Dev Neuropsychol. .

Abstract

This study examined longitudinal predictors of neurodevelopmental outcomes in children with Down syndrome (DS). Participants were assessed at Wave 1 during infancy on measures of looking behavior and caregivers provided infant sensory ratings. At Wave 2, child-age participants completed a developmental assessment and caregivers provided ratings of executive function, ADHD symptoms, and autism symptoms. Longer looking durations and greater sensory dysregulation during infancy were predictive of higher ADHD symptom ratings and other neurodevelopmental outcomes during childhood. The findings suggest that early indicators of neurodevelopmental dysregulation may be detectable during infancy in DS.

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Conflict of interest statement

The authors have no conflict of interest in the publication of this article.

References

    1. Antshel KM, & Russo N (2019). Autism Spectrum Disorders and ADHD: Overlapping Phenomenology, Diagnostic Issues, and Treatment Considerations. Current Psychiatry Reports, 21(5), 34. 10.1007/s11920-019-1020-5 - DOI - PubMed
    1. Bedford R, Pickles A, Gliga T, Elsabbagh M, Charman T, Johnson MH, & BASIS Team. (2014). Additive effects of social and non-social attention during infancy relate to later autism spectrum disorder. Developmental Science, 17(4), 612–620. 10.1111/desc.12139 - DOI - PMC - PubMed
    1. Ben-Sasson A, Soto TW, Martínez-Pedraza F, & Carter AS (2013). Early sensory over-responsivity in toddlers with autism spectrum disorders as a predictor of family impairment and parenting stress. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 54(8), 846–853. 10.1111/jcpp.12035 - DOI - PMC - PubMed
    1. Blankenship TL, Slough MA, Calkins SD, Deater-Deckard K, Kim-Spoon J, & Bell MA (2019). Attention and executive functioning in infancy: Links to childhood executive function and reading achievement. Developmental Science, 22(6), e12824. 10.1111/desc.12824 - DOI - PMC - PubMed
    1. Bull MJ (2020). Down Syndrome. The New England Journal of Medicine, 382(24), 2344–2352. 10.1056/NEJMra1706537 - DOI - PubMed

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