A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study

Irma M Vlasac^{1

2}, Gregory W Bormes^{1

3}, Elizabeth Do¹, Selma S Benkhoukha¹, Naby Diallo¹, Noah L Fryou¹, Siena Gioia¹, Oluwaseun Akeju⁴, Clarence Joseph¹, Anne Kuan⁵, Jennifer Lapan⁵, David Oluwadara⁵, The Pepper Team⁵, Shadab A Rahman^{6

3}, Richa Saxena^{1

2

3

4}, Frank A J L Scheer^{2

6

3

7

8

9}, M Brandon Westover¹⁰, John W Winkelman¹¹, Faraji Woodson¹, Jacqueline M Lane^{1

2

3

4}

Affiliations

¹ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
² Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
³ Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
⁴ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁵ Data Science Platform, Broad Institute, Cambridge, MA, USA.
⁶ Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
⁷ Nutrition Obesity Research Center at Harvard (NORCH), Boston, MA, USA.
⁸ Division of Nutrition, Harvard Medical School, Boston, MA, USA.
⁹ The Mary Horrigan Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, MA, USA.
¹⁰ Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
¹¹ Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

PMID: 37555446
DOI: 10.1093/sleep/zsad197

A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study

Irma M Vlasac et al. Sleep. 2023.

. 2023 Aug 9:zsad197.

doi: 10.1093/sleep/zsad197. Online ahead of print.

Authors

Affiliations

¹ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
² Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
³ Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
⁴ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁵ Data Science Platform, Broad Institute, Cambridge, MA, USA.
⁶ Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
⁷ Nutrition Obesity Research Center at Harvard (NORCH), Boston, MA, USA.
⁸ Division of Nutrition, Harvard Medical School, Boston, MA, USA.
⁹ The Mary Horrigan Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, MA, USA.
¹⁰ Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
¹¹ Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

PMID: 37555446
DOI: 10.1093/sleep/zsad197

Abstract

The Circadia Study (Circadia) is a novel "direct-to-participant" research study investigating the genetics of circadian rhythm disorders of advanced and delayed sleep phase and non-24 hour rhythms. The goals of the Circadia Study are twofold: (i) to create an easy-to-use toolkit for at-home circadian phase assessment for patients with circadian rhythm disorders through the use of novel in-home based surveys, tests, and collection kits; and (ii) create a richly phenotyped patient resource for genetic studies that will lead to new genetic loci associated with circadian rhythm disorders revealing possible loci of interest to target in the development of therapeutics for circadian rhythm disorders. Through these goals, we aim to broaden our understanding and elucidate the genetics of circadian rhythm disorders across a diverse patient population while increasing accessibility to circadian rhythm disorder diagnostics reducing health disparities through self-directed at-home dim light melatonin onset (DLMO) collections.

Keywords: Advanced Sleep-Wake Phase Disorder; Circadian rhythm disorders; Circadian rhythms; Delayed Sleep-Wake Phase Disorder; Dim Light Melatonin Onset; Melatonin; Non-24-Hour Sleep-Wake Disorder.

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A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study

Affiliations

A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study

Authors

Affiliations

Abstract

Grants and funding

LinkOut - more resources

Full Text Sources