When Development of the Alveolar Gas Exchange Unit Fails: Universal Single-Cell Lessons from Rare Monogenic Disorders

Jonas C Schupp^{1

2

3}, Naftali Kaminski¹

Affiliations

¹ Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven, Connecticut.
² Respiratory Medicine Hannover Medical School Hannover, Germany.
³ German Center for Lung Research Biomedical Research in Endstage and Obstructive Lung Disease Hannover Hannover, Germany.

Editorial

Jonas C Schupp et al. Am J Respir Crit Care Med. 2023.

. 2023 Sep 15;208(6):652-654.

doi: 10.1164/rccm.202307-1271ED.

Jonas C Schupp^{1

2

3}, Naftali Kaminski¹

¹ Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine New Haven, Connecticut.
² Respiratory Medicine Hannover Medical School Hannover, Germany.
³ German Center for Lung Research Biomedical Research in Endstage and Obstructive Lung Disease Hannover Hannover, Germany.

No abstract available

Comment on

Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia.
Guo M, Wikenheiser-Brokamp KA, Kitzmiller JA, Jiang C, Wang G, Wang A, Preissl S, Hou X, Buchanan J, Karolak JA, Miao Y, Frank DB, Zacharias WJ, Sun X, Xu Y, Gu M, Stankiewicz P, Kalinichenko VV, Wambach JA, Whitsett JA. Guo M, et al. Am J Respir Crit Care Med. 2023 Sep 15;208(6):709-725. doi: 10.1164/rccm.202210-2015OC. Am J Respir Crit Care Med. 2023. PMID: 37463497 Free PMC article.

1. Vincent M, Karolak JA, Deutsch G, Gambin T, Popek E, Isidor B, et al. Clinical, histopathological, and molecular diagnostics in lethal lung developmental disorders. Am J Respir Crit Care Med . 2019;200:1093–1101. - PMC - PubMed
1. Kamp JC, Neubert L, Ackermann M, Stark H, Plucinski E, Shah HR, et al. A morphomolecular approach to alveolar capillary dysplasia. Am J Pathol . 2022;192:1110–1121. - PubMed
1. Kalinichenko VV, Gusarova GA, Kim IM, Shin B, Yoder HM, Clark J, et al. Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol . 2004;286:L521–L530. - PubMed
1. Mahlapuu M, Enerbäck S, Carlsson P. Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development . 2001;128:2397–2406. - PubMed
1. Guo M, Wikenheiser-Brokamp KA, Kitzmiller JA, Jiang C, Wang G, Wang A, et al. Single cell multiomics identifies cells and genetic networks underlying alveolar capillary dysplasia. Am J Respir Crit Care Med . 2023;208:709–725. - PMC - PubMed