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. 2023 Aug 9;3(8):e0002270.
doi: 10.1371/journal.pgph.0002270. eCollection 2023.

Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations

Pradeep Kumar  1 , Chinmoyee Das  1 , Udayabhanu Das  1 , Arvind Kumar  1 , Nidhi Priyam  1 , Varsha Ranjan  2 , Damodar Sahu  2 , Sanjay K Rai  3 , Sheela V Godbole  4 , Elangovan Arumugam  5 , Lakshmi Pvm  6 , Shanta Dutta  7 , H Sanayaima Devi  8 , Arvind Pandey  2   9 , Dandu Chandra Sekhar Reddy  10 , Sanjay Mehendale  9   11 , Shobini Rajan  1
Affiliations

Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations

Pradeep Kumar et al. PLOS Glob Public Health. .

Abstract

The government of India has adopted the elimination of vertical transmission of HIV as one of the five high-level goals under phase V of the National AIDS and STD Control Programme (NACP). In this paper, we present the data from HIV estimations 2021 for India and select States detailing the progress as well as the attributable causes for vertical transmissions. The NACP spearheads work on mathematical modelling to estimate HIV burden based on the periodically conducted sentinel surveillance for guiding program implementation and policymaking. Using the results of the latest round of HIV Estimations in 2021, we analysed the mother-to-child transmission (MTCT) during the perinatal and postnatal (breastfeeding) period. In 2021, overall, around 5,000 [3,000-7,800] vertical transmissions were estimated nationally with 58% being perinatal infections and remaining during breastfeeding. MTCT at 6 weeks was around 12.95% [9.45-16.02] with the final transmission rate at 24.25% [18.50-29.50]. Overall, 57% of vertical transmissions were among HIV-positive mothers who did not receive ART during pregnancy or breastfeeding, 19% among mothers who dropped off ART during pregnancy or delivery, and 18% among mothers who were infected during pregnancy or breastfeeding. There were significant variations between States. Depending upon the States, the programme needs to focus on the intervention domains of timely engagement in antenatal care-HIV testing-ART initiation as well as programme retention and adherence support. Equally important would be strengthening the strategic information to generate related evidence for inputting India and State-specific parameters improving the MTCT-related modelled estimates.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Stacked bar showing distribution of total estimated vertical transmission in 2021 by timing of infections and ART status.
Fig 2
Fig 2. Proportional distribution of total estimated vertical transmission in 2021 by perinatal or post-natal infection.
See this image and copyright information in PMC

References

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