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Comment
. 2023 Aug 22;120(34):e2310870120.
doi: 10.1073/pnas.2310870120. Epub 2023 Aug 9.

Inducing indigestion in malaria parasites: Genetic manipulations of a proton pump

Akhil B Vaidya  1
Affiliations
Comment

Inducing indigestion in malaria parasites: Genetic manipulations of a proton pump

Akhil B Vaidya. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
DV and hemoglobin digestion in a malaria parasite growing inside a RBC. Abbreviations: PVM, parasitophorous vacuole membrane; PPM, parasite plasma membrane; DV, digestive vacuole; Hb, hemoglobin; CQ, chloroquine; CQ2+, diprotonated chloroquine.
See this image and copyright information in PMC

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References

    1. Goldberg D. E., Plasmodial hemoglobin degradation: An ordered pathway in a specialized organelle. Infect. Agents Dis. 1, 207–211 (1992). - PubMed
    1. Goldberg D. E., Hemoglobin degradation. Curr. Top. Microbiol. Immunol. 295, 275–291 (2005). - PubMed
    1. Ginsburg H., Ward S. A., Bray P. G., An integrated model of chloroquine action. Parasitol. Today 15, 357–360 (1999). - PubMed
    1. Saliba K. J., et al. , Acidification of the malaria parasite’s digestive vacuole by a H+-ATPase and a H+-pyrophosphatase. J. Biol. Chem. 278, 5605–5612 (2003). - PubMed
    1. Alder A., et al. , The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake. Proc. Natl. Acad. Sci. U.S.A. 120, e2306420120 (2023). - PMC - PubMed

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