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Comment
. 2023 Aug 8;56(8):1699-1701.
doi: 10.1016/j.immuni.2023.07.013.

Resident dendritic cell density in the lymph node paracortex is preDC-estined

Rafael S Czepielewski  1 , Gwendalyn J Randolph  2
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Comment

Resident dendritic cell density in the lymph node paracortex is preDC-estined

Rafael S Czepielewski et al. Immunity. .
Free article

Abstract

Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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