Take my breath away: TAM-ing anti-cancer immunity in hypoxic niches
- PMID: 37557077
- DOI: 10.1016/j.immuni.2023.07.010
Take my breath away: TAM-ing anti-cancer immunity in hypoxic niches
Abstract
Hypoxia is a major driver of tumor aggressiveness and therapy resistance in GBM. In this issue of Immunity, Sattiraju et al. functionally link hypoxia with diminished anti-cancer immunity caused by sequestration of immunosuppressive TAMs and CTLs in pseudopalisades in GBM.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression.Immunity. 2023 Aug 8;56(8):1825-1843.e6. doi: 10.1016/j.immuni.2023.06.017. Epub 2023 Jul 13. Immunity. 2023. PMID: 37451265 Free PMC article.
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