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Comment
. 2023 Aug 8;56(8):1706-1708.
doi: 10.1016/j.immuni.2023.07.006.

Hard CiDRE revs up macrophage infectivity in COVID-19

Mallar Bhattacharya  1
Affiliations
Free article
Comment

Hard CiDRE revs up macrophage infectivity in COVID-19

Mallar Bhattacharya. Immunity. .
Free article

Abstract

IL-10 has been linked to COVID-19 severity, but whether it is causal is unclear. In this issue of Immunity, Mitsui et al. find that a specific single-nucleotide polymorphism (SNP) results in expression of an IL10RB-IFNAR2 fusion protein that intensifies IL-10-mediated induction of ACE2 expression and viral infectivity of macrophages.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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