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. 2023 Jul 25:11:1080700.
doi: 10.3389/fpubh.2023.1080700. eCollection 2023.

Ebola vaccine uptake and attitudes among healthcare workers in North Kivu, Democratic Republic of the Congo, 2021

Reena H Doshi  1 , Stephanie C Garbern  2 , Shibani Kulkarni  1 , Shiromi M Perera  3 , Monica K Fleming  1 , Rigobert Fraterne Muhayangabo  4 , Arsene Balene Ombeni  4 , Dieula Delissaint Tchoualeu  1 , Ruth Kallay  1 , Elizabeth Song  5 , Jasmine Powell  5 , Monique Gainey  6 , Bailey Glenn  7 , Ruffin Mitume Mutumwa  4 , Stephane Hans Bateyi Mustafa  8 , Giulia Earle-Richardson  9 , Hongjiang Gao  1 , Neetu Abad  1 , Gnakub Norbert Soke  10 , David L Fitter  1 , Terri B Hyde  1 , Dimitri Prybylski  1 , Adam C Levine  3   4 , Mohamed F Jalloh  11 , Eta Ngole Mbong  4
Affiliations

Ebola vaccine uptake and attitudes among healthcare workers in North Kivu, Democratic Republic of the Congo, 2021

Reena H Doshi et al. Front Public Health. .

Abstract

Introduction: During the 2018-2020 Ebola virus disease (EVD) outbreak in the eastern part of the Democratic Republic of the Congo (DRC), prevention and control measures, such as Ebola vaccination were challenging by community mistrust. We aimed to understand perceptions regarding Ebola vaccination and identify determinants of Ebola vaccine uptake among HCWs.

Methods: In March 2021, we conducted a cross-sectional survey among 438 HCWs from 100 randomly selected health facilities in three health zones (Butembo, Beni, Mabalako) affected by the 10th EVD outbreak in North Kivu, DRC. HCWs were eligible if they were ≥ 18 years and were working in a health facility during the outbreak. We used survey logistic regression to assess correlates of first-offer uptake (i.e., having received the vaccine the first time it was offered vs. after subsequent offers).

Results: Of the 438 HCWs enrolled in the study, 420 (95.8%) reported that they were eligible and offered an Ebola vaccine. Among those offered vaccination, self-reported uptake of the Ebola vaccine was 99.0% (95% confidence interval (CI) [98.5-99.4]), but first-offer uptake was 70.2% (95% CI [67.1, 73.5]). Nearly all HCWs (94.3%; 95% CI [92.7-95.5]) perceived themselves to be at risk of contracting EVD. The most common concern was that the vaccine would cause side effects (65.7%; 95% CI [61.4-69.7]). In the multivariable analysis, mistrust of the vaccine source or how the vaccine was produced decreased the odds of first-time uptake.

Discussion: Overall uptake of the Ebola vaccine was high among HCWs, but uptake at the first offer was substantially lower, which was associated with mistrust of the vaccine source. Future Ebola vaccination efforts should plan to make repeated vaccination offers to HCWs and address their underlying mistrust in the vaccines, which can, in turn, improve community uptake.

Keywords: Democratic Republic of the Congo; Ebola; Ebola vaccine; Ebola virus disease (EVD); vaccine acceptance; vaccine hesitancy; vaccines.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Map of selected health zones in North Kivu (Beni, Butembo, Mabalako), Democratic Republic of the Congo, 2021.
See this image and copyright information in PMC

References

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