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. 1986;27(2):145-66.

A recent aetiological study on facial clefting in Hungary

  • PMID: 3756014

A recent aetiological study on facial clefting in Hungary

A Czeizel et al. Acta Paediatr Hung. 1986.

Abstract

A case-control epidemiological and family study was organized of 2024 index patients born between 1970 and 1976 affected by isolated cleft lip +/- cleft palate, isolated posterior cleft palate and multiple congenital abnormalities including facial clefting and of their matched control cases. The specific rate of affected parents and sibs was 2.4% and 4.2% in the isolated cleft lip +/- cleft palate sample, while 2.2% and 3.2% in the isolated posterior cleft palate group. The proportion of polygenic liability was about 77 +/- 8% in isolated cleft lip +/- cleft palate cases. Among teratogens, the triggering impact of certain anticonvulsants was confirmed.

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