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. 2023 Jul 25:13:1205358.
doi: 10.3389/fonc.2023.1205358. eCollection 2023.

Risk and prediction of multiple primary malignancies after early gastric cancer

Na Chen  1 , Lei Shi  1 , Jian Ge  1 , Ruzhen Jia  1 , Junmei Jiang  1
Affiliations

Risk and prediction of multiple primary malignancies after early gastric cancer

Na Chen et al. Front Oncol. .

Erratum in

Abstract

Background: Patients with early gastric cancer have increased risk of developing multiple primary malignancies (MPM) due to improved survival rates. The purpose of this study was to evaluate the clinicopathological features of MPM and to generate a useful tool for predicting the development of MPM after early gastric cancer.

Methods: We selected 1025 early gastric cancer patients with complete medical records for a retrospective analysis. The Cox proportional risk regression model was used to analyze the independent risk factors for the development of MPM in early gastric cancer. RStudio software was used to compare the OS of early gastric cancer patients with and without MPM, and a nomogram was established to predict the probability of MPM 1-, 2-, 3-year after early gastric cancer. The predictive effectiveness of the nomogram was evaluated by the C-index and calibration curve. Decision curve analysis (DCA) measured the applicability of the nomogram to clinical practice.

Results: Of the 1025 patients with early gastric cancer, 66 patients (6.4%) had 69 primary cancers other than early gastric cancer. They had a median follow-up of 41 months, and their cumulative incidence of MPM was 4.9%, 5.4% and 5.9% after 1-, 2-, and 3- year, respectively. Oesophageal cancer was the most frequently detected MPM, followed by lung and colorectal cancers. Male (p=0.038), age ≥65 years (p=0.003), smoking history (p=0.036), and lymph node metastasis (p=0.013) were independent risk factors for MPM in patients with early gastric cancer. Patients with early gastric cancer with MPM had a worse OS prognosis than patients with early gastric cancer without MPM (p<0.001). The internally validated nomogram predicted the probability of developing MPM after early gastric cancer (C index= 0.697). The calibration chart showed that the predicted probability of MPM in early gastric cancer was similar to the observed result, and the DCA showed strong clinical practicability.

Conclusion: After the diagnosis and treatment of early gastric cancer, we should be alert to the possibility of MPM and perform regular and careful monitoring.

Keywords: early gastric cancer; multiple primary malignancies; nomogram; predictive factor; predictive tool.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The overall survival of early gastric cancer patients with and without MPM.
Figure 2
Figure 2
Nomogram for predicting the 1-, 2-, and 3-year probability of developing metachronous MPM.
Figure 3
Figure 3
Calibration plots for the 1-, 2-, and 3-year nomogram predictions.
Figure 4
Figure 4
DCA curves of the nomogram for predicting MPM.
See this image and copyright information in PMC

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