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Case Reports
. 2023 Jul 7:14:234.
doi: 10.25259/SNI_339_2023. eCollection 2023.

Female monozygotic twins with sacral myelomeningocele

Affiliations
Case Reports

Female monozygotic twins with sacral myelomeningocele

Bamidele Oludele Adebayo et al. Surg Neurol Int. .

Abstract

Background: Concurrent myelomeningocele in twins is a rare clinical presentation, only reported twice in Nigeria.

Case description: We present a set of identical female twins from Nigeria. Both twins were females that presented at 3 years with low back swelling since birth, associated with bisphincteric dysfunction but normal motor and sensory functions in the lower extremities. They had repair of myelomeningocele 2 months after presentation and there was no new deficit postoperatively.There was no family history of neural tube defects and it would have been good to do genetic studies in this case but we do not have facilities for such.

Conclusion: This is the first reported case of identical twins with concurrent myelomeningocele and preserved motor functions in the lower limbs in Nigeria and West Africa.

Keywords: Monozygotic; Myelomeningocele; Twins.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1:
Figure 1:
Lumbosacral swelling.
Figure 2:
Figure 2:
Untethered spinal cord.
Figure 3:
Figure 3:
Four-month post repair, 1 and 2 refer to twin 1 and twin 2 respectively.

References

    1. Adeloye A. Identical myelomeningoceles in a set of non-identical Nigerian twins. Ghana Med J. 1974;1:289.
    1. Adzick NS. Fetal myelomeningocele: Natural history, pathophysiology, and in-utero intervention. Semin Fetal Neonatal Med. 2010;15:9–14. - PMC - PubMed
    1. Copp AJ, Adzick NS, Chitty LS, Fletcher JM, Holmbeck GN, Shaw GM. Spina bifida. Nat Rev Dis Primers. 2015;1:15007. - PMC - PubMed
    1. Deak KL, Siegel DG, George TM, Gregory S, Ashley-Koch A, Speer MC, et al. Further evidence for a maternal genetic effect and a sex-influenced effect contributing to risk for human neural tube defects. Birth Defects Res A Clin Mol Teratol. 2008;82:662–9. - PMC - PubMed
    1. De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC, Rayco-Solon P. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev. 2015;12:CD007950. - PMC - PubMed

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