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. 1986 Aug;22(2):194-7.
doi: 10.1111/j.1365-2125.1986.tb05250.x.

Sparteine oxidation is practically abolished in quinidine-treated patients

R Brinn, K Brøsen, L F Gram, T Haghfelt, S V Otton

Sparteine oxidation is practically abolished in quinidine-treated patients

R Brinn et al. Br J Clin Pharmacol. 1986 Aug.

Abstract

In eight patients a sparteine-test was carried out immediately before and after 1 week of treatment with quinidine 600-800 mg day-1. Before treatment one patient was classified as a poor metaboliser (metabolic ratio: greater than or equal to 20), and seven patients as extensive metabolisers. During quinidine treatment, the formation of sparteine metabolites (2- and 5-dehydrosparteine) was practically abolished. Patients initially classified as extensive metabolisers thus exhibited the phenotype of poor metabolisers during quinidine treatment.

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