The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper

Agata Bielecka-Dabrowa^{1

2}, Maciej Banach^{1

2

3}, Andrzej Wittczak¹, Arrigo F G Cicero^{4

5

6}, Amani Kallel^{7

8}, Raimondas Kubilius^{9

10}, Dimitri P Mikhailidis¹¹, Amirhossein Sahebkar^{12

13

14

15}, Anca Pantea Stoian¹⁶, Dragos Vinereanu^{17

18}, Peter E Penson^{19

20}, Stephan von Haehling^{21

22}

Affiliations

¹ Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
² Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
³ Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.
⁴ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
⁵ Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
⁶ Hypertension and Cardiovascular Risk Research Group, Medical and Surgical Sciences Department, Sant'Orsola-Malpighi University Hospital, Bologna, Italy.
⁷ University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis, Tunisia.
⁸ Laboratory of Biochemistry, Rabta University Hospital, Tunis, Tunisia.
⁹ Department of Rehabilitation, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
¹⁰ Department of Rehabilitation, Lithuanian University of Health Sciences, Kaunas, Lithuania.
¹¹ Department of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London Medical School, University College London (UCL) and Department of Clinical Biochemistry, Royal Free Hospital Campus, UCL, London, UK.
¹² Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
¹³ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
¹⁴ School of Medicine, The University of Western Australia, Perth, Australia.
¹⁵ Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
¹⁶ Faculty of Medicine, Diabetes, Nutrition and Metabolic Diseases, Carol Davila University, Bucharest, Romania.
¹⁷ University Emergency Hospital of Bucharest, Bucharest, Romania.
¹⁸ Cardiology and Cardiovascular Surgery Department, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
¹⁹ Clinical Pharmacy and Therapeutics Research Group, School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
²⁰ Liverpool Centre for Cardiovascular Science, Liverpool, UK.
²¹ Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany.
²² German Center for Cardiovascular Research (DZHK), Göttingen, Germany.

PMID: 37560745
PMCID: PMC10408027
DOI: 10.5114/aoms/167799

The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper

Agata Bielecka-Dabrowa et al. Arch Med Sci. 2023.

. 2023 Jun 9;19(4):841-864.

doi: 10.5114/aoms/167799. eCollection 2023.

Authors

Affiliations

¹ Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
² Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
³ Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.
⁴ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
⁵ Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
⁶ Hypertension and Cardiovascular Risk Research Group, Medical and Surgical Sciences Department, Sant'Orsola-Malpighi University Hospital, Bologna, Italy.
⁷ University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis, Tunisia.
⁸ Laboratory of Biochemistry, Rabta University Hospital, Tunis, Tunisia.
⁹ Department of Rehabilitation, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
¹⁰ Department of Rehabilitation, Lithuanian University of Health Sciences, Kaunas, Lithuania.
¹¹ Department of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London Medical School, University College London (UCL) and Department of Clinical Biochemistry, Royal Free Hospital Campus, UCL, London, UK.
¹² Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
¹³ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
¹⁴ School of Medicine, The University of Western Australia, Perth, Australia.
¹⁵ Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
¹⁶ Faculty of Medicine, Diabetes, Nutrition and Metabolic Diseases, Carol Davila University, Bucharest, Romania.
¹⁷ University Emergency Hospital of Bucharest, Bucharest, Romania.
¹⁸ Cardiology and Cardiovascular Surgery Department, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
¹⁹ Clinical Pharmacy and Therapeutics Research Group, School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
²⁰ Liverpool Centre for Cardiovascular Science, Liverpool, UK.
²¹ Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany.
²² German Center for Cardiovascular Research (DZHK), Göttingen, Germany.

PMID: 37560745
PMCID: PMC10408027
DOI: 10.5114/aoms/167799

Abstract

Muscle wasting is one of the main causes for exercise intolerance and ventilatory inefficiency in patients with heart failure and a strong predictor of frailty and reduced survival. The prevalence of sarcopenia is at least 20% in patients with heart failure. Patients with heart failure often have subclinical systemic inflammation, which may exert sustained effects on skeletal muscle. Besides exercise, nutrition should also be carefully evaluated as an appropriate diet with selected nutraceuticals may be able to stimulate muscle anabolism and inhibit muscle catabolism. This review summarizes the epidemiological and clinical trial evidence supporting the recommendations for the use of nutraceuticals with anti-inflammatory properties in heart failure and provides an overview of the state of the evidence for nutraceutical supplementation to prevent and/or mitigate heart failure muscle wasting.

Keywords: hand grip strength; heart failure; inflammation; muscle wasting; nutraceuticals; sarcopenia.

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Conflict of interest statement

Peter E. Penson has received honoraria and/or travel reimbursement for events sponsored by AKCEA, Amgen, AMRYT, Link Medical, Mylan, Napp, Sanofi; Maciej Banach: speakers bureau: Amgen, Daichii Sankyo, Kogen, KRKA, Polpharma, Mylan/Viatris, Novartis, Novo-Nordisk, Sanofi-Aventis, Teva, Zentiva; consultant to Amgen, Daichii Sankyo, Esperion, NewAmsterdam, Novartis, Novo-Nordisk, Polfarmex, Sanofi-Aventis; Grants from Amgen, Daichii Sankyo, Mylan/Viatris, and Sanofi; CMO at Nomi Biotech Corporation, CMDO at the Longevity Group (LU); all other authors have no conflict of interest.

References

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The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper

Affiliations

The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper

Authors

Affiliations

Abstract

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources